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Akela Kuwahara

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Recent Articles
1.
Sy M, Chauhan J, Prescott K, Imam A, Kraus A, Beleza A, et al.
Am J Med Genet A . 2022 Sep; 188(12):3492-3504. PMID: 36135330
Esophageal atresia/tracheoesophageal fistula (EA/TEF) is a life-threatening birth defect that often occurs with other major birth defects (EA/TEF+). Despite advances in genetic testing, a molecular diagnosis can only be made...
2.
Lewis A, Kuwahara A, Franzosi J, Bush J
Cell Rep . 2022 Mar; 38(11):110510. PMID: 35294885
The mechanisms coupling fate specification of distinct tissues to their physical separation remain to be understood. The trachea and esophagus differentiate from a single tube of definitive endoderm, requiring the...
3.
Kuwahara A, Lewis A, Coombes C, Leung F, Percharde M, Bush J
Elife . 2020 Jun; 9. PMID: 32515350
The genome-scale transcriptional programs that specify the mammalian trachea and esophagus are unknown. Though NKX2-1 and SOX2 are hypothesized to be co-repressive master regulators of tracheoesophageal fates, this is untested...