Akaash K Mishra
Overview
Explore the profile of Akaash K Mishra including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
136
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0
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Recent Articles
1.
Shin O, Monticelli S, Hjorth C, Hornet V, Doyle M, Abelson D, et al.
Cell Rep
. 2024 Jul;
43(7):114502.
PMID: 39002130
Crimean-Congo hemorrhagic fever virus can cause lethal disease in humans yet there are no approved medical countermeasures. Viral glycoprotein GP38, exclusive to Nairoviridae, is a target of protective antibodies and...
2.
Wrapp D, Ye X, Ku Z, Su H, Jones H, Wang N, et al.
Sci Adv
. 2022 Mar;
8(10):eabm2546.
PMID: 35275718
Human cytomegalovirus (HCMV) encodes multiple surface glycoprotein complexes to infect a variety of cell types. The HCMV Pentamer, composed of gH, gL, UL128, UL130, and UL131A, enhances entry into epithelial,...
3.
Mishra A, Hellert J, Freitas N, Guardado-Calvo P, Haouz A, Fels J, et al.
Science
. 2021 Nov;
375(6576):104-109.
PMID: 34793197
Crimean-Congo hemorrhagic fever virus (CCHFV) is the most widespread tick-borne zoonotic virus, with a 30% case fatality rate in humans. Structural information is lacking in regard to the CCHFV membrane...
4.
Fels J, Maurer D, Herbert A, Wirchnianski A, Vergnolle O, Cross R, et al.
Cell
. 2021 Jun;
184(13):3486-3501.e21.
PMID: 34077751
Crimean-Congo hemorrhagic fever virus (CCHFV) is a World Health Organization priority pathogen. CCHFV infections cause a highly lethal hemorrhagic fever for which specific treatments and vaccines are urgently needed. Here,...
5.
Remmel J, Beauchemin K, Mishra A, Frei J, Lai J, Bailey-Kellogg C, et al.
ACS Comb Sci
. 2020 Jun;
22(9):446-456.
PMID: 32574486
Mutagenesis of surface-exposed residues, or "resurfacing", is a protein engineering strategy that can be utilized to disrupt antibody recognition or modulate the capacity of a protein to elicit antibody responses....
6.
Mishra A, Moyer C, Abelson D, Deer D, El Omari K, Duman R, et al.
J Virol
. 2020 Jan;
94(8).
PMID: 31996434
Crimean-Congo hemorrhagic fever virus (CCHFV) is the causative agent of the most widespread tick-borne viral infection in humans. CCHFV encodes a secreted glycoprotein (GP38) of unknown function that is the...
7.
Gavande N, VanderVere-Carozza P, Mishra A, Vernon T, Pawelczak K, Turchi J
J Med Chem
. 2017 Sep;
60(19):8055-8070.
PMID: 28933851
XPA is a unique and essential protein required for the nucleotide excision DNA repair pathway and represents a therapeutic target in oncology. Herein, we are the first to develop novel...
8.
Mishra A, Dormi S, Turchi A, Woods D, Turchi J
Biochem Pharmacol
. 2014 Dec;
93(1):25-33.
PMID: 25449597
Platinum-based chemotherapeutics exert their therapeutic efficacy via the formation of DNA adducts which interfere with DNA replication, transcription and cell division and ultimately induce cell death. Repair and tolerance of...