Ajay Ashok
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Explore the profile of Ajay Ashok including associated specialties, affiliations and a list of published articles.
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23
Citations
199
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Recent Articles
1.
Bioengineering strategy to promote CNS nerve growth and regeneration via chronic glutamate signaling
Chang K, Wu J, Ma T, Hsu S, Cho K, Yu Z, et al.
Acta Biomater
. 2024 Oct;
190:165-177.
PMID: 39427766
Being part of the mature mammalian central nervous system, impairments of the retina and optic nerves caused by trauma or diseases often cannot be restored. Progressive degeneration of retinal ganglion...
2.
Enayati S, Chang K, Lennikov A, Yang M, Lee C, Ashok A, et al.
Neural Regen Res
. 2024 Mar;
19(11):2543-2552.
PMID: 38526290
JOURNAL/nrgr/04.03/01300535-202419110-00034/figure1/v/2024-03-08T184507Z/r/image-tiff Retinitis pigmentosa is a hereditary retinal disease that affects rod and cone photoreceptors, leading to progressive photoreceptor loss. Previous research supports the beneficial effect of electrical stimulation on photoreceptor...
3.
Tai W, Cho K, Kriukov E, Ashok A, Wang X, Monavarfeshani A, et al.
bioRxiv
. 2023 Nov;
PMID: 38014168
The limited regenerative potential of the optic nerve in adult mammals presents a major challenge for restoring vision after optic nerve trauma or disease. The mechanisms of this regenerative failure...
4.
Ashok A, Tai W, Lennikov A, Chang K, Chen J, Li B, et al.
J Cell Biochem
. 2023 Aug;
124(10):1530-1545.
PMID: 37642194
Electrical stimulation (ES) influences neural regeneration and functionality. We here investigate whether ES regulates DNA demethylation, a critical epigenetic event known to influence nerve regeneration. Retinal ganglion cells (RGCs) have...
5.
Adulla A, Patel U, Ashok A, Katiyar P, Kaulakis M, Kritikos A, et al.
Exp Eye Res
. 2022 Dec;
226:109351.
PMID: 36539052
α-Synuclein (α-Syn) is implicated in Parkinson's disease (PD), a neuromotor disorder with prominent visual symptoms. The underlying cause of motor dysfunction has been studied extensively, and is attributed to the...
6.
Yang M, Lennikov A, Chang K, Ashok A, Lee C, Cho K, et al.
BMC Ophthalmol
. 2022 Dec;
22(1):490.
PMID: 36522696
Purpose: Transcorneal electrical stimulation (TcES) is increasingly applied as a therapy for preserving and improving vision in retinal neurodegenerative and ischemic disorders. However, a common complaint about TcES is its...
7.
Lennikov A, Yang M, Chang K, Pan L, Saddala M, Lee C, et al.
Front Cell Dev Biol
. 2022 Sep;
10:980775.
PMID: 36158207
Non-invasive electric stimulation (ES) employing a low-intensity electric current presents a potential therapeutic modality that can be applied for treating retinal and brain neurodegenerative disorders. As neurons are known to...
8.
Ashok A, Pooranawattanakul S, Tai W, Cho K, Utheim T, Cestari D, et al.
Int J Mol Sci
. 2022 Aug;
23(16).
PMID: 36012190
Epigenetic factors are known to influence tissue development, functionality, and their response to pathophysiology. This review will focus on different types of epigenetic regulators and their associated molecular apparatus that...
9.
Chaudhary S, Ashok A, Wise A, Rana N, Kritikos A, Lindner E, et al.
Exp Eye Res
. 2021 Oct;
212:108787.
PMID: 34624335
Recently, we reported β-cleavage of the prion protein (PrP) in human ocular tissues. Here, we explored whether this is unique to the human eye, and its functional implications. A comparison...
10.
Ashok A, Chaudhary S, Wise A, Rana N, McDonald D, Kritikos A, et al.
Antioxidants (Basel)
. 2021 Aug;
10(8).
PMID: 34439501
To evaluate the role of iron in sodium iodate (NaIO)-induced model of age-related macular degeneration (AMD) in ARPE-19 cells in-vitro and in mouse models in-vivo. ARPE-19 cells, a human retinal...