Aisha M Swaih
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Explore the profile of Aisha M Swaih including associated specialties, affiliations and a list of published articles.
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5
Citations
24
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Recent Articles
1.
McCoull W, Thomson C, Braybrooke E, Chan C, Colclough N, Cortes Gonzalez M, et al.
J Med Chem
. 2025 Jan;
68(3):3700-3748.
PMID: 39869768
Despite recent advances in the inhibition of EGFR (epidermal growth factor receptor), there remains a clinical need for new EGFR Exon20 insertion (Ex20Ins) inhibitors that spare EGFR WT. Herein, we...
2.
Thomson C, Braybrooke E, Colclough N, Davies N, Floch N, Greenwood R, et al.
J Med Chem
. 2024 Sep;
PMID: 39340451
Herein, we report the optimization of a series of epidermal growth factor receptor (EGFR) Exon20 insertion (Ex20Ins) inhibitors using structure-based drug design (SBDD), leading to the discovery of compound ,...
3.
Thomson C, Barton P, Braybrooke E, Colclough N, Dong Z, Evans L, et al.
J Med Chem
. 2024 May;
67(11):8988-9027.
PMID: 38770784
Herein, we report the identification and optimization of a series of potent inhibitors of EGFR Exon20 insertions with significant selectivity over wild-type EGFR. A strategically designed HTS campaign, multiple iterations...
4.
Swaih A, Breda C, Sathyasaikumar K, Allcock N, Collier M, Mason R, et al.
Biomedicines
. 2022 Sep;
10(9).
PMID: 36140394
The flavoprotein kynurenine 3-monooxygenase (KMO) is localised to the outer mitochondrial membrane and catalyses the synthesis of 3-hydroxykynurenine from L-kynurenine, a key step in the kynurenine pathway (KP) of tryptophan...
5.
Maddison D, Alfonso-Nunez M, Swaih A, Breda C, Campesan S, Allcock N, et al.
PLoS Genet
. 2020 Nov;
16(11):e1009129.
PMID: 33170836
The enzyme kynurenine 3-monooxygenase (KMO) operates at a critical branch-point in the kynurenine pathway (KP), the major route of tryptophan metabolism. As the KP has been implicated in the pathogenesis...
6.
Johnson R, West C, Swaih A, Folwell B, Smith B, Rowland S, et al.
Environ Microbiol
. 2011 Nov;
14(4):872-82.
PMID: 22118473
Naphthenic acids (NAs) are complex mixtures of carboxylic acids found in weathered crude oils and oil sands, and are toxic, corrosive and persistent. However, little is known about the microorganisms...