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Aiman S El-Khatib

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Citations 363
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Recent Articles
1.
Mansour A, Khattab M, El-Khatib A, Awaad A, El-Refaie W, El-Mezayen N
Life Sci . 2024 Aug; 353:122939. PMID: 39094905
Aims: Transactivation of insulin-growth-factor-receptor (IGF-1R) by angiotensin-II-type-1-receptor (AT-1R) was only demonstrated in vascular-smooth-muscle cells and has never been tested in breast-cancer (BC). This investigation addressed the impact of chronic AT-1R...
2.
Mansour H, Mohamed A, Khattab M, El-Khatib A
Brain Res . 2024 Mar; 1834:148893. PMID: 38554797
Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra. The dopamine D3 receptor (D3R) plays a significant role in the pathogenesis and treatment...
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Mansour H, Mohamed A, Khattab M, El-Khatib A
Neuroscience . 2023 Dec; 537:32-46. PMID: 38040085
Parkinson's disease (PD) is the second most common neurodegenerative disease, characterized by abnormal α-synuclein misfolding and aggregation, mitochondrial dysfunction, oxidative stress, as well as progressive death of dopaminergic neurons in...
5.
Abdelrahman B, Hammam O, El-Khatib A, Attia Y
Biochem Biophys Res Commun . 2023 Nov; 688:149122. PMID: 37951152
Damage-associated molecular patterns released upon hepatocyte injury ensuing non-alcoholic steatohepatitis (NASH) can stimulate innate immunity by activating NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome, thereby triggering pro-inflammatory cascades...
6.
Mansour H, El-Khatib A
Ageing Res Rev . 2023 Nov; 92:102114. PMID: 37924981
Parkinson's disease (PD) is a debilitating neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substania nigra (SN) and is associated with progressive motor impairment. PD is classified...
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Mansour H, Mohamed A, Khattab M, El-Khatib A
Food Chem Toxicol . 2023 Oct; 181:114069. PMID: 37820786
Parkinson's disease (PD) is characterized by motor impairments and progressive dopaminergic neuronal death in the substantia nigra (SN). Recently, the involvement of other regulated cell death (RCD) machineries has been...
8.
Abdelrahman B, El-Khatib A, Attia Y
Life Sci . 2023 Sep; 332:122124. PMID: 37742738
Vitamin D (VD) is a secosteroid hormone that is renowned for its crucial role in phospho-calcium homeostasis upon binding to the nuclear vitamin D receptor (VDR). Over and above, the...
9.
Mansour H, Mohamed A, Khattab M, El-Khatib A
Eur J Pharmacol . 2023 Jun; 954:175875. PMID: 37385578
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor deficits induced by dopaminergic neuronal death in the substantia nigra (SN). Finding a successful neuroprotective therapy is still challenging despite...
10.
Mansour H, Mohamed A, El-Khatib A, Khattab M
Ageing Res Rev . 2023 Jan; 85:101841. PMID: 36608709
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder in the world. Motor impairment seen in PD is associated with dopaminergic neurotoxicity in the striatum, and dopaminergic neuronal death...