Aileen F Keating
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Explore the profile of Aileen F Keating including associated specialties, affiliations and a list of published articles.
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99
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1090
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Recent Articles
1.
Timme K, Inyang I, White H, Keating A
Toxicol Sci
. 2025 Feb;
204(1):9-19.
PMID: 39910959
7,12-Dimethylbenz[a]anthracene (DMBA) is a polycyclic aromatic hydrocarbon that causes female infertility via DNA damage, and the ovary has the capacity to mitigate DMBA exposure via the action of proteins including...
2.
Good S, Antwi-Boasiako C, Gonzalez-Alvarez M, Buol B, Baumgard L, Keating A, et al.
Toxicol Sci
. 2025 Feb;
PMID: 39901320
Perfluorooctanoic acid (PFOA), a legacy perfluoroalkyl substance with immuno- and repro-toxicant effects, has poorly characterized bioaccumulation and distribution patterns in female pigs. The potential for heat stress to influence PFOA...
3.
Keating A, Ross J, Baumgard L
Reproduction
. 2024 Oct;
168(6.
PMID: 39401133
In Brief: This review describes how heat stress causes systemic endocrine and metabolic alterations that contribute to intracellular ovarian perturbations, resulting in female infertility. Abstract: Heat stress (HS) in mammals...
4.
Studer J, Kiefer Z, Koester L, Johnson E, Schmitz-Esser S, Farkas A, et al.
J Anim Sci
. 2024 Sep;
102.
PMID: 39298285
Postpartum dysgalactia syndrome (PDS) is a condition affecting periparturient sows, characterized by a reduction in milk and colostrum synthesis shortly after farrowing. Insufficient milk production results in substantial economic losses...
5.
Gonzalez-Alvarez M, Antwi-Boasiako C, Keating A
Toxics
. 2024 Jul;
12(7.
PMID: 39058107
Per- and poly-fluoroalkylated substances (PFAS) are a large group of chemicals that persist both in the environment and in the body. Legacy PFAS, e.g., perfluorooctanoic acid and perfluorooctane sulfonic acid,...
6.
Pre-pubertal obesity compromises ovarian oxidative stress, DNA repair and chemical biotransformation
Timme K, Gonzalez-Alvarez M, Keating A
Toxicol Appl Pharmacol
. 2024 Jun;
489:116981.
PMID: 38838792
Obesity in adult females impairs fertility by altering oxidative stress, DNA repair and chemical biotransformation. Whether prepubertal obesity results in similar ovarian impacts is under-explored. The objective of this study...
7.
Novbatova G, Fox I, Timme K, Keating A
Biol Reprod
. 2024 May;
111(2):496-511.
PMID: 38813940
Obesity and ovotoxicant exposures impair female reproductive health with greater ovotoxicity reported in obese relative to lean females. The mother and developing fetus are vulnerable to both during gestation. 7,12-dimethylbenz[a]anthracene...
8.
Roach C, Mayorga E, Baumgard L, Ross J, Keating A
J Anim Sci
. 2024 Apr;
102.
PMID: 38666409
Zearalenone (ZEN), a nonsteroidal estrogenic mycotoxin, causes endocrine disruption and porcine reproductive dysfunction. Heat stress (HS) occurs when exogenous and metabolic heat accumulation exceeds heat dissipation. Independently, HS and ZEN...
9.
Gonzalez-Alvarez M, Inyang I, Keating A
Toxicol Appl Pharmacol
. 2024 Apr;
486:116930.
PMID: 38626870
Obesity impairs oocyte quality, fertility, pregnancy maintenance, and is associated with offspring birth defects. The model ovotoxicant, 7,12-dimethylbenz[a]anthracene (DMBA), causes ovarian DNA damage and follicle loss. Both DMBA-induced chemical biotransformation...
10.
Rishi J, Timme K, White H, Kerns K, Keating A
Biol Reprod
. 2024 Apr;
111(2):483-495.
PMID: 38625059
Both obesity and exposure to environmental genotoxicants, such as 7,12-dimethylbenz[a]anthracene, negatively impair female reproductive health. Hyperphagic lean KK.Cg-a/a (n = 8) and obese KK.Cg-Ay/J (n = 10) mice were exposed...