Ahmed A Othman
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Explore the profile of Ahmed A Othman including associated specialties, affiliations and a list of published articles.
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111
Citations
2449
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Recent Articles
1.
Younis I, Weber E, Nelson C, Qin A, Watkins T, Othman A
J Clin Pharmacol
. 2025 Mar;
PMID: 40052566
Fenofibrate is contraindicated in patients with advanced hepatic fibrosis due to limited clinical data. We evaluated the pharmacokinetics and safety of fenofibrate in participants with mild hepatic impairment (phase 1...
2.
Sorour D, Atta M, Mohamed A, Alfayomy N, Othman A, Eweida R
Geriatr Nurs
. 2025 Jan;
62(Pt A):72-80.
PMID: 39879728
Background: Climate change is a global health concern that affects all of humanity, but it disproportionately impacts older adults, particularly those living in rural communities. Older adults lack the ability...
3.
Sathe A, Diderichsen P, Fauchet F, Phan S, Girish S, Othman A
Clin Pharmacol Ther
. 2024 Nov;
117(2):570-578.
PMID: 39543869
Sacituzumab govitecan (SG), a Trop-2-directed antibody-drug conjugate, is approved for patients with metastatic triple-negative breast cancer (mTNBC) who received ≥2 prior systemic therapies (≥1 in metastatic setting). Exposure-response (E-R) relationships...
4.
Weber E, Younis I, Nelson C, Qin A, Watkins T, Othman A
Clin Pharmacokinet
. 2024 Sep;
63(10):1423-1434.
PMID: 39292376
Background And Objective: Firsocostat is an oral, liver-targeted inhibitor of acetyl-CoA carboxylase in clinical development for the treatment of metabolic dysfunction-associated steatohepatitis. This work evaluated the potential drug-drug interactions (DDIs)...
5.
Younis I, Nelson C, Weber E, Shen G, Qin A, Xiao D, et al.
J Clin Pharmacol
. 2024 Aug;
64(12):1586-1593.
PMID: 39213138
Cilofexor, an oral farnesoid X receptor agonist, and firsocostat, an oral, liver-targeted inhibitor of acetyl-coenzyme A carboxylase, are being investigated in combination with semaglutide for the treatment of metabolic dysfunction-associated...
6.
Dauki A, Rajakumaraswamy N, Trowe T, Weng W, Lin K, Elboudjwarej E, et al.
Clin Transl Sci
. 2024 Aug;
17(8):e70011.
PMID: 39169685
Conventional dendritic cells subtype 1 (cDC1) play a vital role in the priming and expansion of tumor-specific CD8+ T cells and their recruitment to tumor microenvironment. However, cDC1s are often...
7.
Samineni D, Venkatakrishnan K, Othman A, Pithavala Y, Poondru S, Patel C, et al.
Clin Pharmacol Ther
. 2024 May;
116(3):531-545.
PMID: 38752712
The landscape of oncology drug development has witnessed remarkable advancements over the last few decades, significantly improving clinical outcomes and quality of life for patients with cancer. Project Optimus, introduced...
8.
Odegard J, Othman A, Lin K, Wang A, Nazareno J, Yoon O, et al.
J Immunother Cancer
. 2024 Apr;
12(4).
PMID: 38604815
Background: Checkpoint inhibitors targeting the programmed cell death 1 (PD-1)/programmed cell death 1 ligand 1 (PD-L1) pathway are effective therapies in a range of immunogenic cancer types. Blocking this pathway...
9.
Sathe A, Singh I, Singh P, Diderichsen P, Wang X, Chang P, et al.
Clin Pharmacokinet
. 2024 Apr;
63(5):669-681.
PMID: 38578394
Background And Objective: Sacituzumab govitecan (SG) is an antibody-drug conjugate composed of an antibody with affinity for Trop-2 coupled to SN-38 via hydrolyzable linker. SG is approved for patients with...
10.
Younis I, Nelson C, Weber E, Qin A, Watkins T, Othman A
J Clin Pharmacol
. 2024 Mar;
64(7):878-886.
PMID: 38520128
Firsocostat is an oral, liver-targeted inhibitor of acetyl-coenzyme A carboxylase in development for the treatment of metabolic dysfunction-associated steatohepatitis. Hepatic organic anion transporting polypeptides play a significant role in the...