Ahmed A Eldeeb
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Explore the profile of Ahmed A Eldeeb including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
79
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Recent Articles
1.
Adel H, Eldeeb A, Hamdy F
Reumatol Clin (Engl Ed)
. 2025 Feb;
21(1):101803.
PMID: 39894628
Introduction And Objectives: Glomerulonephritis is a heterogenous group of diseases which is diagnosed mainly by renal biopsy. This study aims to assess nailfold capillaroscopic changes in patients with glomerular diseases....
2.
Dubovichenko M, Nedorezova D, Patra C, Drozd V, Andrianov V, Ashmarova A, et al.
Chembiochem
. 2024 Oct;
25(24):e202400665.
PMID: 39471339
Oligonucleotide gene therapy (OGT) can be used to suppress specific RNA in cells and thus has been explored for gene therapy. Despite extensive effort, there is no clinically significant OGT...
3.
Nedorezova D, Dubovichenko M, Eldeeb A, Nur M, Bobkov G, Ashmarova A, et al.
Chemistry
. 2024 May;
30(40):e202401580.
PMID: 38757205
Both tight and specific binding of folded biological mRNA is required for gene silencing by oligonucleotide gene therapy agents. However, this is fundamentally impossible using the conventional oligonucleotide probes according...
4.
Nour M, Drozd V, Lemeshko E, Tafran L, Salimova A, Kulikova A, et al.
Chem Commun (Camb)
. 2024 Apr;
60(33):4427-4430.
PMID: 38563262
Threshold antisense oligonucleotide constructs were designed to cleave mRNA within different biomarker concentrations. The mRNA cleavage is activated by 2.6, 7.5 or 39.5 nM of biomarker depending on the construct...
5.
Nedorezova D, Dubovichenko M, Kalnin A, Nour M, Eldeeb A, Ashmarova A, et al.
Chembiochem
. 2023 Oct;
25(1):e202300637.
PMID: 37870555
Cleavage of biological mRNA by DNAzymes (Dz) has been proposed as a variation of oligonucleotide gene therapy (OGT). The design of Dz-based OGT agents includes computational prediction of two RNA-binding...
6.
Samaan E, Eldeeb A, Ibrahim A, Erman M, Sabry A, Mahmoud M
Ther Apher Dial
. 2023 Apr;
27(4):655-660.
PMID: 37028928
Background: Chronic kidney disease (CKD) is associated with a state of chronic inflammation. This study aimed to investigate effects of Ramadan fasting on the markers of chronic inflammation and gut...
7.
Patra C, Eldeeb A
ChemMedChem
. 2023 Feb;
18(7):e202300040.
PMID: 36734637
Therapeutic nucleic acid agents (TNA) can be activated by a marker RNA sequence followed by initiation of targeted RNA cleavage. This property can be used in conditional cell suppression, e. ...
8.
Drozd V, Eldeeb A, Kolpashchikov D, Nedorezova D
Nucleic Acid Ther
. 2022 Jul;
32(5):412-420.
PMID: 35852843
Antisense oligonucleotide technology is one of the most successful gene therapy (GT) approaches. However, low selectivity of antisense agents limits their application as anticancer drugs. To achieve activation of antisense...
9.
Gomes de Oliveira A, Dubovichenko M, Eldeeb A, Wanjohi J, Zablotskaya S, Kolpashchikov D
Chembiochem
. 2021 Jan;
22(10):1750-1754.
PMID: 33433948
Oligonucleotide gene therapy (OGT) agents suppress specific mRNAs in cells and thus reduce the expression of targeted genes. The ability to unambiguously distinguish cancer from healthy cells can solve the...
10.
Eldeeb A, Mahmoud M, Ibrahim A, Yousef E, Sabry A
Saudi J Kidney Dis Transpl
. 2020 Jul;
31(3):582-588.
PMID: 32655044
Arterial stiffness (AS) increases progressively in patients with chronic kidney disease (CKD). It is a strong predictor of cardiovascular and all-cause mortality. This study aims at evaluate of the effect...