Adrian R Wilkie
Overview
Explore the profile of Adrian R Wilkie including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
173
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Recent Articles
1.
Becker I, Wilkie A, Nikols E, Carminita E, Roweth H, Tilburg J, et al.
Sci Adv
. 2024 Jun;
10(25):eadl6153.
PMID: 38896608
Platelet-producing megakaryocytes (MKs) primarily reside in the bone marrow, where they duplicate their DNA content with each cell cycle resulting in polyploid cells with an intricate demarcation membrane system. While...
2.
Becker I, Wilkie A, Unger B, Sciaudone A, Fatima F, Tsai I, et al.
Haematologica
. 2023 Sep;
109(3):915-928.
PMID: 37675512
Megakaryocytes (MK) undergo extensive cytoskeletal rearrangements as they give rise to platelets. While cortical microtubule sliding has been implicated in proplatelet formation, the role of the actin cytoskeleton in proplatelet...
3.
Wilkie A, Sharma M, Coughlin M, Pesola J, Ericsson M, Lawler J, et al.
Viruses
. 2022 Mar;
14(3).
PMID: 35336886
After herpesviruses encapsidate their genomes in replication compartments (RCs) within the nuclear interior, capsids migrate to the inner nuclear membrane (INM) for nuclear egress. For human cytomegalovirus (HCMV), capsid migration...
4.
Lundberg Slingsby M, Vijey P, Tsai I, Roweth H, Couldwell G, Wilkie A, et al.
Haematologica
. 2021 Feb;
107(2):519-531.
PMID: 33567808
Antisense oligonucleotides (ASO) are DNA-based, disease-modifying drugs. Clinical trials with 2'-O-methoxyethyl (2'MOE) ASO have shown dose- and sequence-specific lowering of platelet counts according to two phenotypes. Phenotype 1 is a...
5.
French S, Vijey P, Karhohs K, Wilkie A, Horin L, Ray A, et al.
J Thromb Haemost
. 2020 Jul;
18(10):2701-2711.
PMID: 32662223
Background: The mechanisms that regulate platelet biogenesis remain unclear; factors that trigger megakaryocytes (MKs) to initiate platelet production are poorly understood. Platelet formation begins with proplatelets, which are cellular extensions...
6.
Sharda A, Barr A, Harrison J, Wilkie A, Fang C, Mendez L, et al.
Blood
. 2020 Jul;
136(24):2824-2837.
PMID: 32614949
von Willebrand factor (VWF) is an essential hemostatic protein that is synthesized in endothelial cells and stored in Weibel-Palade bodies (WPBs). Understanding the mechanisms underlying WPB biogenesis and exocytosis could...
7.
Sen P, Wilkie A, Ji F, Yang Y, Taylor I, Velazquez-Palafox M, et al.
Sci Adv
. 2020 Jun;
6(17):eaax9856.
PMID: 32494628
Cytomegalovirus (CMV) is an important cause of morbidity and mortality in the immunocompromised host. In transplant recipients, a variety of clinically important "indirect effects" are attributed to immune modulation by...
8.
9.
Battinelli E, Thon J, Okazaki R, Peters C, Vijey P, Wilkie A, et al.
Blood Adv
. 2019 Oct;
3(20):3092-3098.
PMID: 31648331
In addition to their primary roles in hemostasis and thrombosis, platelets participate in many other physiological and pathological processes, including, but not limited to inflammation, wound healing, tumor metastasis, and...
10.
Tarnita R, Wilkie A, DeCaprio J
J Virol
. 2018 Oct;
93(1).
PMID: 30333173
Host range (HR) mutants of simian virus 40 (SV40) containing mutations in the C terminus of large T antigen fail to replicate efficiently or form plaques in restrictive cell types....