Adrian Najer
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Explore the profile of Adrian Najer including associated specialties, affiliations and a list of published articles.
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31
Citations
515
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Recent Articles
1.
Chen K, Najer A, Charchar P, Saunders C, Thanapongpibul C, Klockner A, et al.
Nat Commun
. 2024 Nov;
15(1):10321.
PMID: 39609415
Staphylococcus aureus is a leading cause of nosocomial implant-associated infections, causing significant morbidity and mortality, underscoring the need for rapid, non-invasive, and cost-effective diagnostics. Here, we optimise the synthesis of...
2.
Thanapongpibul C, Rifaie-Graham O, Ojansivu M, Najer A, Kim H, Bakker S, et al.
Adv Mater
. 2024 Oct;
36(49):e2408000.
PMID: 39417762
Efficient delivery of therapeutic proteins and vaccine antigens to intracellular targets is challenging due to generally poor cell membrane permeation and endolysosomal entrapment causing degradation. Herein, these challenges are addressed...
3.
Najer A
Smart Med
. 2024 Aug;
3(2):e20230046.
PMID: 39188697
Global health faces an immense burden from infectious diseases caused by viruses and intracellular protozoan parasites such as the coronavirus disease (COVID-19) and malaria, respectively. These pathogens propagate through the...
4.
Najer A, Kim J, Saunders C, Che J, Baum J, Stevens M
ACS Infect Dis
. 2024 Jan;
10(2):732-745.
PMID: 38271991
Severe malaria is a life-threatening condition that is associated with a high mortality. Severe infections are mediated primarily by high parasitemia and binding of infected red blood cells (iRBCs) to...
5.
Saunders C, Foote J, Wojciechowski J, Cammack A, Pedersen S, Doutch J, et al.
ACS Nano
. 2023 Jun;
17(12):11713-11728.
PMID: 37279338
The intrinsic heterogeneity of many nanoformulations is currently challenging to characterize on both the single particle and population level. Therefore, there is great opportunity to develop advanced techniques to describe...
6.
Creamer A, Fiego A, Agliano A, Prados-Martin L, Hogset H, Najer A, et al.
Adv Mater
. 2023 Mar;
36(20):e2300413.
PMID: 36905683
Semiconducting polymer nanoparticles (SPNs) are explored for applications in cancer theranostics because of their high absorption coefficients, photostability, and biocompatibility. However, SPNs are susceptible to aggregation and protein fouling in...
7.
Najer A, Rifaie-Graham O, Yeow J, Adrianus C, Chami M, Stevens M
Macromol Biosci
. 2022 Nov;
23(8):e2200424.
PMID: 36447300
A significant factor hindering the clinical translation of polymersomes as vesicular nanocarriers is the limited availability of comparative studies detailing their interaction with blood plasma proteins compared to liposomes. Here,...
8.
Rifaie-Graham O, Yeow J, Najer A, Wang R, Sun R, Zhou K, et al.
Nat Chem
. 2022 Nov;
15(1):110-118.
PMID: 36344820
The circadian rhythm generates out-of-equilibrium metabolite oscillations that are controlled by feedback loops under light/dark cycles. Here we describe a non-equilibrium nanosystem comprising a binary population of enzyme-containing polymersomes capable...
9.
Najer A, Blight J, Ducker C, Gasbarri M, Brown J, Che J, et al.
ACS Cent Sci
. 2022 Oct;
8(9):1238-1257.
PMID: 36188342
Infectious diseases continue to pose a substantial burden on global populations, requiring innovative broad-spectrum prophylactic and treatment alternatives. Here, we have designed modular synthetic polymer nanoparticles that mimic functional components...
10.
Kim H, Yeow J, Najer A, Kit-Anan W, Wang R, Rifaie-Graham O, et al.
Adv Sci (Weinh)
. 2022 Jul;
9(27):e2200239.
PMID: 35901502
Constructing artificial systems that effectively replace or supplement natural biological machinery within cells is one of the fundamental challenges underpinning bioengineering. At the sub-cellular scale, artificial organelles (AOs) have significant...