Adrian Kohut
Overview
Explore the profile of Adrian Kohut including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
50
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0
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Recent Articles
1.
Lugo Santiago N, Ituarte P, Kohut A, Senguttuvan R, Ruel N, Nelson R, et al.
Gynecol Oncol Rep
. 2024 Jul;
54:101430.
PMID: 38973983
Objective: Living in a food desert is a known negative health risk, with recent literature finding an associated higher mortality in patients with cancers. Gynecologic cancers have not specifically been...
2.
Martincuks A, Zhang C, Austria T, Li Y, Huang R, Lugo Santiago N, et al.
J Immunother Cancer
. 2024 Apr;
12(4).
PMID: 38580335
Background: Ovarian cancer is the most lethal gynecological malignancy, with limited treatment options after failure of standard therapies. Despite the potential of poly(ADP-ribose) polymerase inhibitors in treating DNA damage response...
3.
Ladbury C, Eustace N, Kassardjian A, Amini A, Chen Y, Wang E, et al.
Brachytherapy
. 2024 Mar;
23(3):237-247.
PMID: 38553406
Purpose: Brachytherapy is a critical component of the standard-of-care curative radiotherapy regimen for women with locally advanced cervical cancer (LACC). However, existing literature suggests that many patients will not receive...
4.
Wei C, Wang E, Ma L, Zhou Y, Zheng L, Hampel H, et al.
Cancers (Basel)
. 2023 Dec;
15(23).
PMID: 38067377
Background: Mutations in the DNA polymerase delta 1 (POLD1) exonuclease domain cause DNA proofreading defects, hypermutation, hereditary colorectal and endometrial cancer, and are predictive of immunotherapy response. Exonuclease activity is...
5.
Zhao Q, Kohut A, Li Y, Martincuks A, Austria T, Zhang C, et al.
Front Oncol
. 2022 Nov;
12:966492.
PMID: 36324587
Recently, poly(ADP-ribosyl)ation polymerase inhibitors (PARPis), which induce synthetic lethality of tumor cells with DNA damage repair defects, have emerged as a promising therapy for ovarian, breast, and pancreatic cancer. Although...
6.
Girda E, Hou J, Nelson D, Finlayson M, Buckley de Meritens A, Chekmareiva M, et al.
Int J Gynecol Cancer
. 2022 Jun;
32(8):1032-1038.
PMID: 35750354
Objective: Preclinical evidence and early clinical trials have demonstrated the activity of SPL-108, a targeted agent that inhibits CD44 mediated induction of multidrug resistance specifically to paclitaxel and platinum agents....
7.
Kohut A, Whitaker T, Walter L, Li S, Han E, Lee S, et al.
Int Urogynecol J
. 2022 May;
34(1):177-183.
PMID: 35501570
Introduction And Hypothesis: At our institution, every patient seen by the gynecologic oncology service is screened for pelvic floor dysfunction. This study was aimed at determining if a combined surgical...
8.
Martincuks A, Song J, Kohut A, Zhang C, Li Y, Zhao Q, et al.
Front Oncol
. 2021 Dec;
11:724104.
PMID: 34956861
Despite the promising activity of poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi) in many cancer types with defects in the DNA damage response the majority of the treated patients acquire PARPi resistance...
9.
Raoof M, Malhotra G, Kohut A, OLeary M, Frankel P, Tran T, et al.
Ann Surg Oncol
. 2021 Aug;
29(1):175-185.
PMID: 34387765
Background: Peritoneal metastases (PM) from ovarian, gastric, appendiceal, or colorectal origin can be treated via cytoreductive surgery with or without the addition of hyperthermic intraperitoneal chemotherapy (HIPEC) for selected patients....
10.
Jodry D, Blemur D, Nguyen M, Kuhn T, Easley K, Wang H, et al.
J Low Genit Tract Dis
. 2021 Feb;
25(2):81-85.
PMID: 33631779
Objective: The aim of the study was to elucidate the risk factors underlying abnormal cytology-based cervical cancer screening (Pap testing) in justice-involved women (JIW) compared with non-JIW in an urban...