Adrian Heilbut
Overview
Explore the profile of Adrian Heilbut including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
2434
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0
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Recent Articles
1.
Hachigian L, Carmona V, Fenster R, Kulicke R, Heilbut A, Sittler A, et al.
Cell Rep
. 2017 Dec;
21(10):2688-2695.
PMID: 29212017
Alteration of corticostriatal glutamatergic function is an early pathophysiological change associated with Huntington's disease (HD). The factors that regulate the maintenance of corticostriatal glutamatergic synapses post-developmentally are not well understood....
2.
Heiman M, Heilbut A, Francardo V, Kulicke R, Fenster R, Kolaczyk E, et al.
Proc Natl Acad Sci U S A
. 2014 Mar;
111(12):4578-83.
PMID: 24599591
Levodopa treatment is the major pharmacotherapy for Parkinson's disease. However, almost all patients receiving levodopa eventually develop debilitating involuntary movements (dyskinesia). Although it is known that striatal spiny projection neurons...
3.
Talkowski M, Rosenfeld J, Blumenthal I, Pillalamarri V, Chiang C, Heilbut A, et al.
Cell
. 2012 Apr;
149(3):525-37.
PMID: 22521361
Balanced chromosomal abnormalities (BCAs) represent a relatively untapped reservoir of single-gene disruptions in neurodevelopmental disorders (NDDs). We sequenced BCAs in patients with autism or related NDDs, revealing disruption of 33...
4.
Chiang C, Jacobsen J, Ernst C, Hanscom C, Heilbut A, Blumenthal I, et al.
Nat Genet
. 2012 Mar;
44(4):390-7, S1.
PMID: 22388000
We defined the genetic landscape of balanced chromosomal rearrangements at nucleotide resolution by sequencing 141 breakpoints from cytogenetically interpreted translocations and inversions. We confirm that the recently described phenomenon of...
5.
Talkowski M, Ernst C, Heilbut A, Chiang C, Hanscom C, Lindgren A, et al.
Am J Hum Genet
. 2011 Apr;
88(4):469-81.
PMID: 21473983
The contribution of balanced chromosomal rearrangements to complex disorders remains unclear because they are not detected routinely by genome-wide microarrays and clinical localization is imprecise. Failure to consider these events...
6.
Suzuki Y, St Onge R, Mani R, King O, Heilbut A, Labunskyy V, et al.
Nat Methods
. 2011 Jan;
8(2):159-64.
PMID: 21217751
Phenotypes that might otherwise reveal a gene's function can be obscured by genes with overlapping function. This phenomenon is best known within gene families, in which an important shared function...
7.
Ewing R, Chu P, Elisma F, Li H, Taylor P, Climie S, et al.
Mol Syst Biol
. 2007 Mar;
3:89.
PMID: 17353931
Mapping protein-protein interactions is an invaluable tool for understanding protein function. Here, we report the first large-scale study of protein-protein interactions in human cells using a mass spectrometry-based approach. The...
8.
Bader G, Heilbut A, Andrews B, Tyers M, Hughes T, Boone C
Trends Cell Biol
. 2003 Jul;
13(7):344-56.
PMID: 12837605
The challenge of large-scale functional genomics projects is to build a comprehensive map of the cell including genome sequence and gene expression data, information on protein localization, structure, function and...
9.
Ho Y, Gruhler A, Heilbut A, Bader G, Moore L, Adams S, et al.
Nature
. 2002 Jan;
415(6868):180-3.
PMID: 11805837
The recent abundance of genome sequence data has brought an urgent need for systematic proteomics to decipher the encoded protein networks that dictate cellular function. To date, generation of large-scale...