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Adrian Hapca

Explore the profile of Adrian Hapca including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 16
Citations 288
Followers 0
Related Specialties
General Medicine
Gastroenterology
Science
Top 10 Co-Authors
Peter T Donnan
Alison Avenell
Karen T Smith
Margaret M Band
Miles D Witham
Allan D Struthers
Jacob George
Claire J Steves
Celia L Gregson
Simon Kerr
Published In
PLoS One
BMJ Open
Br J Clin Pharmacol
Thorax
Lancet Neurol
Affiliations
Soon will be listed here.
Recent Articles
1.
Association of bradykinin receptor 2 (BDKRB2) variants with physical performance and muscle mass: Findings from the LACE sarcopenia trial
Shrestha A, Bashir T, Achison M, Adamson S, Akpan A, Aspray T, et al.
PLoS One . 2024 Aug; 19(8):e0307268. PMID: 39093910
Introduction: Understanding genetic contributors to sarcopenia (age-related loss of muscle strength and mass) is key to finding effective therapies. Variants of the bradykinin receptor 2 (BDKRB2) have been linked to...
2.
Activin type I receptor polymorphisms and body composition in older individuals with sarcopenia-Analyses from the LACE randomised controlled trial
Bashir T, Achison M, Adamson S, Akpan A, Aspray T, Avenell A, et al.
PLoS One . 2023 Nov; 18(11):e0294330. PMID: 37963137
Background: Ageing is associated with changes in body composition including an overall reduction in muscle mass and a proportionate increase in fat mass. Sarcopenia is characterised by losses in both...
3.
ACE I/D genotype associates with strength in sarcopenic men but not with response to ACE inhibitor therapy in older adults with sarcopenia: Results from the LACE trial
Rossios C, Bashir T, Achison M, Adamson S, Akpan A, Aspray T, et al.
PLoS One . 2023 Oct; 18(10):e0292402. PMID: 37862321
Background: Angiotensin II (AII), has been suggested to promote muscle loss. Reducing AII synthesis, by inhibiting angiotensin converting enzyme (ACE) activity has been proposed as a method to inhibit muscle...
4.
Randomized clinical trial: Direct-acting antivirals as treatment for hepatitis C in people who inject drugs: Delivered in needle and syringe programs via directly observed therapy versus fortnightly collection
Beer L, Inglis S, Malaguti A, Byrne C, Sharkey C, Robinson E, et al.
J Viral Hepat . 2022 May; 29(8):646-653. PMID: 35582875
Hepatitis C virus (HCV) treatment in people who inject drugs (PWID) is delivered within settings frequented by PWID, such as needle and syringe programs (NSP). The optimal direct-acting antiviral (DAA)...
5.
Effect of perindopril or leucine on physical performance in older people with sarcopenia: the LACE randomized controlled trial
Achison M, Adamson S, Akpan A, Aspray T, Avenell A, Band M, et al.
J Cachexia Sarcopenia Muscle . 2022 Feb; 13(2):858-871. PMID: 35174663
Background: This trial aimed to determine the efficacy of leucine and/or perindopril in improving physical function in older people with sarcopenia. Methods: Placebo-controlled, parallel group, double-blind, randomized two-by-two factorial trial....
6.
Promoting smoking cessation during pregnancy: A feasibility and pilot trial of a digital storytelling intervention delivered via text-messaging
King E, Cheyne H, Abhyankar P, Elders A, Grindle M, Hapca A, et al.
Patient Educ Couns . 2022 Jan; 105(7):2562-2572. PMID: 35063311
Objective: Smoking during pregnancy causes risks to mother and infant health. We investigated the feasibility and likely success of SKIP-IT, a narrative and picture-based smoking cessation intervention delivered via text...
7.
Clinical effectiveness of pharmacist-led versus conventionally delivered antiviral treatment for hepatitis C virus in patients receiving opioid substitution therapy: a pragmatic, cluster-randomised trial
Radley A, de Bruin M, Inglis S, Donnan P, Hapca A, Barclay S, et al.
Lancet Gastroenterol Hepatol . 2020 Jun; 5(9):809-818. PMID: 32526210
Background: Highly effective direct-acting antiviral drugs provide the opportunity to eliminate hepatitis C virus (HCV) infection, but established pathways can be ineffective. We aimed to examine whether a community pharmacy...
8.
Game of Stones: feasibility randomised controlled trial of how to engage men with obesity in text message and incentive interventions for weight loss
Dombrowski S, McDonald M, van der Pol M, Grindle M, Avenell A, Carroll P, et al.
BMJ Open . 2020 Feb; 10(2):e032653. PMID: 32102807
Objectives: To examine the acceptability and feasibility of narrative text messages with or without financial incentives to support weight loss for men. Design: Individually randomised three-arm feasibility trial with 12...
9.
Intelligent liver function testing (iLFT): A trial of automated diagnosis and staging of liver disease in primary care
Dillon J, Miller M, Robinson E, Hapca A, Rezaeihemami M, Weatherburn C, et al.
J Hepatol . 2019 Jun; 71(4):699-706. PMID: 31226388
Background & Aims: Liver function tests (LFTs) are frequently requested blood tests which may indicate liver disease. LFTs are commonly abnormal, the causes of which can be complex and are...
10.
Cognitive behavioural therapy with optional graded exercise therapy in patients with severe fatigue with myotonic dystrophy type 1: a multicentre, single-blind, randomised trial
Okkersen K, Jimenez-Moreno C, Wenninger S, Daidj F, Glennon J, Cumming S, et al.
Lancet Neurol . 2018 Jun; 17(8):671-680. PMID: 29934199
Background: Myotonic dystrophy type 1 is the most common form of muscular dystrophy in adults and leads to severe fatigue, substantial physical functional impairment, and restricted social participation. In this...