Adele F Holloway
Overview
Explore the profile of Adele F Holloway including associated specialties, affiliations and a list of published articles.
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26
Citations
393
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Recent Articles
1.
Wilkinson E, Raspin K, Malley R, Donovan S, Nott L, Holloway A, et al.
Cancer Med
. 2024 Aug;
13(16):e70122.
PMID: 39164966
Background: Current diagnostic tools are unable to distinguish low-grade indolent prostate cancer (PrCa) from that with a propensity to become metastatic and/or lethal. Recent evidence suggests that reprogramming of the...
2.
Woodworth A, Hardy K, Taberlay P, Dickinson J, Holloway A
J Cell Biochem
. 2024 Apr;
125(6):e30570.
PMID: 38616697
Runt-related transcription factor 1 (RUNX1) plays an important role in normal haematopoietic cell development and function, and its function is frequently disrupted in leukaemia. RUNX1 is widely recognised as a...
3.
Verhoeff T, Holloway A, Dickinson J
Cell Oncol (Dordr)
. 2022 Dec;
46(2):239-250.
PMID: 36512308
Background: Integrins are integral to cell signalling and management of the extracellular matrix, and exquisite regulation of their expression is essential for a variety of cell signalling pathways, whilst disordered...
4.
Verhoeff T, Holloway A, Dickinson J
Breast Cancer Res Treat
. 2022 Jan;
192(1):89-100.
PMID: 35098437
Purpose: ITGA2 encodes the integrin, α2 which mediates metastatic progression, and is a predictor of poor prognosis and chemoresistance in breast cancer. Decreased ITGA2 promoter methylation is implicated as a...
5.
Wilkinson E, Woodworth A, Parker M, Phillips J, Malley R, Dickinson J, et al.
Exp Cell Res
. 2020 May;
392(2):112055.
PMID: 32376286
Examination of epigenetic changes at the ITGB4 gene promoter reveals altered methylation at different stages of prostate tumour progression and these changes may, in part, explain the complex patterns of...
6.
Sutton L, Jeffreys S, Phillips J, Taberlay P, Holloway A, Ambrose M, et al.
Epigenetics
. 2019 Jun;
14(10):989-1002.
PMID: 31208284
Many cancer therapies operate by inducing double-strand breaks (DSBs) in cancer cells, however treatment-resistant cells rapidly initiate mechanisms to repair damage enabling survival. While the DNA repair mechanisms responsible for...
7.
De Paoli-Iseppi R, Prentice L, Marthick J, Thomson R, Holloway A, Dickinson J, et al.
Pathology
. 2018 Aug;
50(6):622-628.
PMID: 30149991
Multiple endocrine neoplasia type 1 (MEN 1) has marked severity variation between individuals with the same mutation. To investigate any relationship between promoter methylation and clinical features, blood and tissue...
8.
Phillips J, Taberlay P, Woodworth A, Hardy K, Brettingham-Moore K, Dickinson J, et al.
J Cell Physiol
. 2017 Sep;
233(4):3439-3453.
PMID: 28926098
Integrins are transmembrane adhesion receptors that play an important role in hematopoiesis by facilitating interactions between hematopoietic cells and extracellular matrix components of the bone marrow and hematopoietic tissues. These...
9.
Cazaly E, Thomson R, Marthick J, Holloway A, Charlesworth J, Dickinson J
Clin Epigenetics
. 2016 Jul;
8:75.
PMID: 27429663
Background: Human methylome mapping in health and disease states has largely relied on Illumina Human Methylation 450k array (450k array) technology. Accompanying this has been the necessary evolution of analysis...
10.
Atashrazm F, Lowenthal R, Dickinson J, Holloway A, Woods G
Oncotarget
. 2016 Jun;
7(29):46028-46041.
PMID: 27329592
The morbidity and mortality associated with current therapies for acute promyelocytic leukemia (APL) remain a significant clinical concern, despite improvements in patient survival. Consequently, the development of adjuvant therapies that...