Adam T Zemla
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Explore the profile of Adam T Zemla including associated specialties, affiliations and a list of published articles.
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14
Citations
72
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Recent Articles
1.
Desautels T, Arrildt K, Zemla A, Lau E, Zhu F, Ricci D, et al.
Nature
. 2024 May;
629(8013):878-885.
PMID: 38720086
The COVID-19 pandemic underscored the promise of monoclonal antibody-based prophylactic and therapeutic drugs and revealed how quickly viral escape can curtail effective options. When the SARS-CoV-2 Omicron variant emerged in...
2.
Sandholtz S, Drocco J, Zemla A, Torres M, Silva M, Allen J
ACS Omega
. 2023 Jun;
8(24):21871-21884.
PMID: 37309388
Minimizing the human and economic costs of the COVID-19 pandemic and future pandemics requires the ability to develop and deploy effective treatments for novel pathogens as soon as possible after...
3.
Desautels T, Arrildt K, Zemla A, Lau E, Zhu F, Ricci D, et al.
bioRxiv
. 2022 Nov;
PMID: 36324800
The COVID-19 pandemic underscored the promise of monoclonal antibody-based prophylactic and therapeutic drugs, but also revealed how quickly viral escape can curtail effective options. With the emergence of the SARS-CoV-2...
4.
Zemla A, Allen J, Kirshner D, Lightstone F
NAR Genom Bioinform
. 2022 Oct;
4(4):lqac078.
PMID: 36225529
We present a structure-based method for finding and evaluating structural similarities in protein regions relevant to ligand binding. PDBspheres comprises an exhaustive library of protein structure regions ('spheres') adjacent to...
5.
Zhu F, Bourguet F, Bennett W, Lau E, Arrildt K, Segelke B, et al.
Sci Rep
. 2022 Jul;
12(1):12489.
PMID: 35864134
Alchemical free energy perturbation (FEP) is a rigorous and powerful technique to calculate the free energy difference between distinct chemical systems. Here we report our implementation of automated large-scale FEP...
6.
Collette N, Lao V, Weilhammer D, Zingg B, Cohen S, Hwang M, et al.
Viruses
. 2020 Nov;
12(11).
PMID: 33198111
The 2014-2016 Zika virus (ZIKV) epidemic in the Americas resulted in large deposits of next-generation sequencing data from clinical samples. This resource was mined to identify emerging mutations and trends...
7.
Borucki M, Collette N, Coffey L, Van Rompay K, Hwang M, Thissen J, et al.
PLoS One
. 2019 Dec;
14(12):e0225699.
PMID: 31809512
The question of how Zika virus (ZIKV) changed from a seemingly mild virus to a human pathogen capable of microcephaly and sexual transmission remains unanswered. The unexpected emergence of ZIKV's...
8.
Pena J, Chen-Harris H, Allen J, Hwang M, Elsheikh M, Mabery S, et al.
Virus Evol
. 2016 Oct;
2(1):vew008.
PMID: 27774301
serial passage of non-pathogenic viruses has been shown to lead to increased viral virulence, and although the precise mechanism(s) are not clear, it is known that both host and viral...
9.
Chaudhury S, AbdulHameed M, Singh N, Tawa G, Dhaeseleer P, Zemla A, et al.
PLoS One
. 2013 May;
8(5):e63369.
PMID: 23704901
In the future, we may be faced with the need to provide treatment for an emergent biological threat against which existing vaccines and drugs have limited efficacy or availability. To...
10.
Cadag E, Vitalis E, Lennox K, Ecale Zhou C, Zemla A
BMC Res Notes
. 2012 Feb;
5:96.
PMID: 22333139
Background: Genes conferring antibiotic resistance to groups of bacterial pathogens are cause for considerable concern, as many once-reliable antibiotics continue to see a reduction in efficacy. The recent discovery of...