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Adam P Faranda

Explore the profile of Adam P Faranda including associated specialties, affiliations and a list of published articles. Areas
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Articles 6
Citations 59
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Recent Articles
1.
Novo S, Faranda A, DAntin J, Wang Y, Shihan M, Barraquer R, et al.
Mol Vis . 2025 Feb; 30:348-367. PMID: 39959166
Purpose: Cataracts are typically treated by phacoemulsification followed by intraocular lens implantation. Studies of mouse models of cataract surgery have revealed that lens epithelial cells rapidly remodel their transcriptome to...
2.
Xiang J, Pompetti A, Faranda A, Wang Y, Novo S, Li D, et al.
Cells . 2023 Nov; 12(22). PMID: 37998373
The late embryonic mouse lens requires the transcription factor ATF4 for its survival although the underlying mechanisms were unknown. Here, RNAseq analysis revealed that E16.5 null mouse lenses downregulate the...
3.
Novo S, Faranda A, Shihan M, Wang Y, Garg A, Duncan M
Cells . 2022 Nov; 11(21). PMID: 36359852
Cataracts are treated by lens fiber cell removal followed by intraocular lens (IOL) implantation into the lens capsule. While effective, this procedure leaves behind numerous lens epithelial cells (LECs) which...
4.
Shihan M, Novo S, Wang Y, Sheppard D, Atakilit A, Arnold T, et al.
JCI Insight . 2021 Sep; 6(21). PMID: 34554928
Fibrotic posterior capsular opacification (PCO), a major complication of cataract surgery, is driven by transforming growth factor-β (TGF-β). Previously, αV integrins were found to be critical for the onset of...
5.
Faranda A, Shihan M, Wang Y, Duncan M
Exp Eye Res . 2021 Jun; 209:108676. PMID: 34146586
The transcriptome of mammalian tissues differs between males and females, and these differences can change across the lifespan, likely regulating known sexual dimorphisms in disease prevalence and severity. Cataract, the...
6.
Faranda A, Shihan M, Wang Y, Duncan M
Exp Eye Res . 2021 Jun; 209:108663. PMID: 34119483
Age is a major risk factor for cataract (ARC). However, the influence of aging on the lens transcriptome is under studied. Lens epithelial (LEC) and fiber cells (LFC) were isolated...
7.
Shihan M, Kanwar M, Wang Y, Jackson E, Faranda A, Duncan M
Matrix Biol . 2020 Mar; 90:79-108. PMID: 32173580
Fibrotic posterior capsular opacification (PCO), one of the major complications of cataract surgery, occurs when lens epithelial cells (LCs) left behind post cataract surgery (PCS) undergo epithelial to mesenchymal transition,...