Adam L Burrack
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Explore the profile of Adam L Burrack including associated specialties, affiliations and a list of published articles.
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17
Citations
698
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Recent Articles
1.
Schmiechen Z, Nanda H, Burrack A, Hickok G, Butler J, Cruz-Hinojoza E, et al.
Cancer Immunol Res
. 2025 Mar;
PMID: 40072469
Agonistic anti-CD40 with anti-PD-1 can elicit objective responses in a small number of patients with pancreatic ductal adenocarcinoma (PDA). Better understanding of their individual effects on the PDA tumor microenvironment...
2.
Patterson M, Burrack A, Xu Y, Hickok G, Schmiechen Z, Becker S, et al.
Cell Rep
. 2023 Jul;
42(7):112732.
PMID: 37402168
Pancreatic ductal adenocarcinoma (PDA) orchestrates a suppressive tumor microenvironment that fosters immunotherapy resistance. Tumor-associated macrophages (TAMs) are the principal immune cell infiltrating PDA and are heterogeneous. Here, by employing macrophage...
3.
Rollins M, Raynor J, Miller E, Butler J, Spartz E, Lahr W, et al.
Nat Commun
. 2023 Feb;
14(1):528.
PMID: 36726009
T cell receptor (TCR) transgenic mice represent an invaluable tool to study antigen-specific immune responses. In the pre-existing models, a monoclonal TCR is driven by a non-physiologic promoter and randomly...
4.
Sackett S, Kaplan S, Mitchell S, Brown M, Burrack A, Grey S, et al.
Transpl Int
. 2022 Dec;
35:10817.
PMID: 36545154
Genome editing has the potential to revolutionize many investigative and therapeutic strategies in biology and medicine. In the field of regenerative medicine, one of the leading applications of genome engineering...
5.
Burrack A, Spartz E, Rollins M, Miller E, Firulyova M, Cruz E, et al.
Cancer Immunol Immunother
. 2022 Dec;
72(6):1461-1478.
PMID: 36472588
Pancreatic ductal adenocarcinoma (PDA) is a lethal and metastatic malignancy resistant to therapy. Elucidating how pancreatic tumor-specific T cells differentiate and are maintained in vivo could inform novel therapeutic avenues...
6.
Burrack A, Schmiechen Z, Patterson M, Miller E, Spartz E, Rollins M, et al.
JCI Insight
. 2022 Apr;
7(7).
PMID: 35393950
We investigate how myeloid subsets differentially shape immunity to pancreatic ductal adenocarcinoma (PDA). We show that tumor antigenicity sculpts myeloid cell composition and functionality. Antigenicity promotes accumulation of type 1...
7.
Stromnes I, Hulbert A, Rollins M, Basom R, Delrow J, Bonson P, et al.
J Immunother Cancer
. 2022 Feb;
10(2).
PMID: 35210305
Background: Achieving robust responses with adoptive cell therapy for the treatment of the highly lethal pancreatic ductal adenocarcinoma (PDA) has been elusive. We previously showed that T cells engineered to...
8.
Yousefzadeh M, Flores R, Zhu Y, Schmiechen Z, Brooks R, Trussoni C, et al.
Nature
. 2021 May;
594(7861):100-105.
PMID: 33981041
Ageing of the immune system, or immunosenescence, contributes to the morbidity and mortality of the elderly. To define the contribution of immune system ageing to organism ageing, here we selectively...
9.
Burrack A, Rollins M, Spartz E, Mesojednik T, Schmiechen Z, Raynor J, et al.
J Immunol
. 2021 Feb;
206(6):1372-1384.
PMID: 33558374
Pancreatic cancer is a particularly lethal malignancy that resists immunotherapy. In this study, using a preclinical pancreatic cancer murine model, we demonstrate a progressive decrease in IFN-γ and granzyme B...
10.
Gill R, Burrack A
Front Immunol
. 2020 Oct;
11:580483.
PMID: 33117387
Memory T lymphocytes constitute a significant problem in tissue and organ transplantation due their contribution to early rejection and their relative resistance to tolerance-promoting therapies. Memory cells generated by environmental...