Adam J Adler
Overview
Explore the profile of Adam J Adler including associated specialties, affiliations and a list of published articles.
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Articles
54
Citations
1730
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Recent Articles
1.
Karginov T, Menoret A, Leclair N, Harrison A, Chandiran K, Suarez-Ramirez J, et al.
Science
. 2024 Sep;
385(6714):eadj1979.
PMID: 39265028
T cell receptor (TCR) sensitivity to peptide-major histocompatibility complex (MHC) dictates T cell fate. Canonical models of TCR sensitivity cannot be fully explained by transcriptional regulation. In this work, we...
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Pitmon E, Meehan E, Ahmadi E, Adler A, Wang K
PLoS One
. 2023 Feb;
18(2):e0280916.
PMID: 36730267
The consumption of processed foods and sugary sodas in Western diets correlates with an increased incidence of obesity, metabolic syndromes such as type 2 diabetes, cardiovascular diseases, and autoimmune diseases...
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Adler A
Immunol Invest
. 2022 Nov;
51(8):2128-2132.
PMID: 36343204
The past decade has seen the advent and widespread use of several immunotherapeutic modalities that have markedly improved treatment outcomes for patients with various cancers. Nevertheless, the study of cancer...
6.
Garcia Cruz D, Giri R, Turro D, Balsbaugh J, Adler A, Rodriguez A
J Immunol
. 2021 Sep;
207(9):2374-2384.
PMID: 34588222
Deficiency of lymphocyte activation gene-3 (LAG3) is significantly associated with increased cardiovascular disease risk with in vitro results demonstrating increased TNF-α and decreased IL-10 secretion from LAG3-deficient human B lymphoblasts....
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Adler A, Mittal P, Hagymasi A, Menoret A, Shen C, Agliano F, et al.
Oncogene
. 2020 Jan;
39(11):2424-2436.
PMID: 31959897
Metastatic tumors that have become resistant to androgen deprivation therapy represent the major challenge in treating prostate cancer. Although these recurrent tumors typically remain dependent on the androgen receptor (AR),...
9.
Chen J, Ye X, Pitmon E, Lu M, Wan J, Jellison E, et al.
J Immunother Cancer
. 2019 Nov;
7(1):324.
PMID: 31775909
Background: The IL-17 family cytokines are potent drivers of colorectal cancer (CRC) development. We and others have shown that IL-17 mainly signals to tumor cells to promote CRC, but the...
10.
Konstorum A, Vella A, Adler A, Laubenbacher R
Sci Rep
. 2019 Jul;
9(1):10862.
PMID: 31350431
Combined agonist stimulation of the TNFR costimulatory receptors 4-1BB (CD137) and OX40(CD134) has been shown to generate supereffector CD8 T cells that clonally expand to greater levels, survive longer, and...