Adam Deane
Overview
Explore the profile of Adam Deane including associated specialties, affiliations and a list of published articles.
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40
Citations
517
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Recent Articles
1.
Raven L, Lever W, MacIsaac R, Greenfield J, Deane A, Plummer M, et al.
Intern Med J
. 2025 Mar;
PMID: 40045881
Background: Diabetic ketoacidosis (DKA) is a hyperglycaemic emergency, and insulin administration is highly protocolised with either variable- or fixed-rate intravenous infusions. There are limited data supporting superiority of one regimen...
2.
Casaer M, Deane A
Curr Opin Clin Nutr Metab Care
. 2025 Feb;
28(2):121-122.
PMID: 39912391
No abstract available.
3.
Bellomo R, Patava J, Van Lancker R, Layios N, Peetermans M, Plummer M, et al.
Pharmacol Res Perspect
. 2024 Oct;
12(5):e70015.
PMID: 39401149
Increased circulating histones correlate with sepsis severity and are a potential therapeutic target. Pre-clinical studies showed benefit with a histone-neutralizing polyanion molecule (STC3141). We aimed to investigate the safety, tolerability,...
4.
Cook D, Deane A, Lauzier F, Zytaruk N, Guyatt G, Saunders L, et al.
N Engl J Med
. 2024 Jun;
391(1):9-20.
PMID: 38875111
Background: Whether proton-pump inhibitors are beneficial or harmful for stress ulcer prophylaxis in critically ill patients undergoing invasive ventilation is unclear. Methods: In this international, randomized trial, we assigned critically...
5.
Wang Y, Parpia S, Ge L, Heels-Ansdell D, Lai H, Esfahani M, et al.
NEJM Evid
. 2024 Jun;
3(7):EVIDoa2400134.
PMID: 38874580
Background: The goal of this systematic review was to examine the efficacy and safety of proton-pump inhibitors for stress ulcer prophylaxis in critically ill patients. Methods: We included randomized trials...
6.
Dennis B, Deane A, Lauzier F, Zytaruk N, Hardie M, Hammond N, et al.
BMC Med Res Methodol
. 2024 May;
24(1):109.
PMID: 38704520
Background: During the COVID-19 pandemic, many intensive care units (ICUs) halted research to focus on COVID-19-specific studies. Objective: To describe the conduct of an international randomized trial of stress ulcer...
7.
Wang Y, Heels-Ansdell D, Ge L, Parpia S, Ibrahim Q, Cook D, et al.
Acta Anaesthesiol Scand
. 2024 Apr;
68(7):983-988.
PMID: 38581102
Background: Proton pump inhibitors (PPIs) are the most commonly prescribed drugs for preventing upper gastrointestinal bleeding in critically ill patients. However, concerns have arisen about the possible harms of using...
8.
Cook D, Deane A, Dionne J, Lauzier F, Marshall J, Arabi Y, et al.
Contemp Clin Trials Commun
. 2024 Apr;
39:101284.
PMID: 38559746
Background: Ascertainment of the severity of the primary outcome of upper gastrointestinal (GI) bleeding is integral to stress ulcer prophylaxis trials. This protocol outlines the adjudication process for GI bleeding...
9.
Heels-Ansdell D, Billot L, Thabane L, Alhazzani W, Deane A, Guyatt G, et al.
Trials
. 2023 Dec;
24(1):796.
PMID: 38057875
Background: The REVISE (Re-Evaluating the Inhibition of Stress Erosions in the ICU) trial will evaluate the impact of the proton pump inhibitor pantoprazole compared to placebo in invasively ventilated critically...
10.
Dennis B, Thabane L, Heels-Ansdell D, Dionne J, Binnie A, Tsang J, et al.
Trials
. 2023 Aug;
24(1):561.
PMID: 37644556
Background: Critically ill patients commonly receive proton pump inhibitors (PPIs) to prevent gastrointestinal (GI) bleeding from stress-induced ulceration. Despite widespread use in the intensive care unit (ICU), observational data suggest...