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Adam D Silverman

Explore the profile of Adam D Silverman including associated specialties, affiliations and a list of published articles. Areas
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Articles 12
Citations 445
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Recent Articles
1.
Ekas H, Wang B, Silverman A, Lucks J, Karim A, Jewett M
ACS Synth Biol . 2024 Oct; 13(10):3389-3399. PMID: 39373325
The design and optimization of metabolic pathways, genetic systems, and engineered proteins rely on high-throughput assays to streamline design-build-test-learn cycles. However, assay development is a time-consuming and laborious process. Here,...
2.
Ekas H, Wang B, Silverman A, Lucks J, Karim A, Jewett M
ACS Synth Biol . 2024 Sep; 13(9):3003-3012. PMID: 39255329
Industrialization and failing infrastructure have led to a growing number of irreversible health conditions resulting from chronic lead exposure. While state-of-the-art analytical chemistry methods provide accurate and sensitive detection of...
3.
Jung J, Rasor B, Rybnicky G, Silverman A, Standeven J, Kuhn R, et al.
ACS Synth Biol . 2023 Sep; 12(10):2909-2921. PMID: 37699423
As the field of synthetic biology expands, the need to grow and train science, technology, engineering, and math (STEM) practitioners is essential. However, the lack of access to hands-on demonstrations...
4.
Phillips E, Silverman A, Joneja A, Liu M, Brown C, Carlson P, et al.
Nat Biomed Eng . 2023 May; 7(12):1571-1582. PMID: 37142844
Nucleic acid assays are not typically deployable in point-of-care settings because they require costly and sophisticated equipment for the control of the reaction temperature and for the detection of the...
5.
Jung K, Rasor B, Rybnicky G, Silverman A, Standeven J, Kuhn R, et al.
bioRxiv . 2023 Jan; PMID: 36711593
As the field of synthetic biology expands, the need to grow and train science, technology, engineering, and math (STEM) practitioners is essential. However, the lack of access to hands-on demonstrations...
6.
Harbaugh S, Silverman A, Chushak Y, Zimlich K, Wolfe M, Thavarajah W, et al.
ACS Synth Biol . 2022 Jul; 11(7):2275-2283. PMID: 35775197
The detection of chemicals using natural allosteric transcription factors is a powerful strategy for point-of-use molecular sensing, particularly using fieldable cell-free gene expression (CFE) systems. However, the reliance of detection...
7.
Silverman A, Akova U, Alam K, Jewett M, Lucks J
ACS Synth Biol . 2020 Feb; 9(3):671-677. PMID: 32078765
Recent advances in cell-free synthetic biology have spurred the development of molecular diagnostics that serve as effective alternatives to whole-cell biosensors. However, cell-free sensors for detecting manmade organic water contaminants...
8.
Thavarajah W, Silverman A, Verosloff M, Kelley-Loughnane N, Jewett M, Lucks J
ACS Synth Biol . 2019 Dec; 9(1):10-18. PMID: 31829623
Advances in biosensor engineering have enabled the design of programmable molecular systems to detect a range of pathogens, nucleic acids, and chemicals. Here, we engineer and field-test a biosensor for...
9.
Liu X, Silverman A, Alam K, Iverson E, Lucks J, Jewett M, et al.
ACS Synth Biol . 2019 Dec; 9(1):84-94. PMID: 31825601
Rapid molecular biosensing is an emerging application area for synthetic biology. Here, we engineer a portable biosensor for cyanuric acid (CYA), an analyte of interest for human and environmental health,...
10.
Silverman A, Karim A, Jewett M
Nat Rev Genet . 2019 Nov; 21(3):151-170. PMID: 31780816
Cell-free biology is the activation of biological processes without the use of intact living cells. It has been used for more than 50 years across the life sciences as a...