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Adam D Hudgins

Explore the profile of Adam D Hudgins including associated specialties, affiliations and a list of published articles. Areas
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Articles 9
Citations 137
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Recent Articles
1.
Jin C, Wang X, Yang J, Kim S, Hudgins A, Gamliel A, et al.
Nat Aging . 2024 Nov; 5(2):275-290. PMID: 39578560
The ovary is the first organ to age in the human body, affecting both fertility and overall health. However, the biological mechanisms underlying human ovarian aging remain poorly understood. Here...
2.
Suryadevara V, Hudgins A, Rajesh A, Pappalardo A, Karpova A, Dey A, et al.
Nat Rev Mol Cell Biol . 2024 Jun; 25(12):1001-1023. PMID: 38831121
Once considered a tissue culture-specific phenomenon, cellular senescence has now been linked to various biological processes with both beneficial and detrimental roles in humans, rodents and other species. Much of...
3.
Wang X, Tazearslan C, Kim S, Guo Q, Contreras D, Yang J, et al.
bioRxiv . 2024 May; PMID: 38746475
Several decades of heterochronic parabiosis (HCPB) studies have demonstrated the restorative impact of young blood, and deleterious influence of aged blood, on physiological function and homeostasis across tissues, although few...
4.
Hudgins A, Zhou S, Arey R, Rosenfeld M, Murphy C, Suh Y
Neuron . 2024 May; 112(13):2112-2129.e4. PMID: 38692279
Genome-wide association studies (GWASs) have uncovered over 75 genomic loci associated with risk for late-onset Alzheimer's disease (LOAD), but identification of the underlying causal genes remains challenging. Studies of induced...
5.
Kim S, Hudgins A, Yang J, Zhu Y, Tu Z, Rosenfeld M, et al.
PLoS One . 2021 Sep; 16(9):e0257265. PMID: 34529725
Type 1 diabetes (T1D) is an organ-specific autoimmune disease, whereby immune cell-mediated killing leads to loss of the insulin-producing β cells in the pancreas. Genome-wide association studies (GWAS) have identified...
6.
Kim S, Hudgins A, Gonzalez B, Milman S, Barzilai N, Vijg J, et al.
Front Genet . 2021 Jun; 12:680560. PMID: 34140970
The rich data from the genome-wide association studies (GWAS) and phenome-wide association studies (PheWAS) offer an unprecedented opportunity to identify the biological underpinnings of age-related disease (ARD) risk and multimorbidity....
7.
Walters R, Arias E, Diaz A, Burgos E, Guan F, Tiano S, et al.
Cell Rep . 2018 Oct; 25(3):663-676.e6. PMID: 30332646
A hallmark of aging is a decline in metabolic homeostasis, which is attenuated by dietary restriction (DR). However, the interaction of aging and DR with the metabolome is not well...
8.
Hudgins A, Tazearslan C, Tare A, Zhu Y, Huffman D, Suh Y
Front Genet . 2018 Mar; 9:59. PMID: 29527222
Cellular senescence is a state of irreversible cellular growth arrest accompanied by distinct changes in gene expression and the acquisition of a complex proinflammatory secretory profile termed the senescence-associated secretory...
9.
Heavner M, Hudgins A, Rajwani R, Morales J, Govind S
Curr Opin Insect Sci . 2015 Feb; 6:61-67. PMID: 25642411
species lack most hallmarks of adaptive immunity yet are highly successful against an array of natural microbial pathogens and metazoan enemies. When attacked by figitid parasitoid wasps, fruit flies deploy...