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» Authors » Abdullah Mohammed Al-Majid

Abdullah Mohammed Al-Majid

Explore the profile of Abdullah Mohammed Al-Majid including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 49
Citations 261
Followers 0
Related Specialties
Chemistry
Biology
Biochemistry
Top 10 Co-Authors
Assem Barakat
Mohammad Shahidul Islam
M Ali
Sammer Yousuf
Hazem A Ghabbour
Matti Haukka
Saeed Alshahrani
Yahia Nasser Mabkhot
M Iqbal Choudhary
Zaheer Ul-Haq
Published In
Molecules
Bioorg Chem
Chem Cent J
Int J Mol Sci
ACS Omega
Affiliations
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Recent Articles
11.
Design, Synthesis and In Vitro Evaluation of Spirooxindole-Based Phenylsulfonyl Moiety as a Candidate Anti-SAR-CoV-2 and MERS-CoV-2 with the Implementation of Combination Studies
Barakat A, Mostafa A, Ali M, Al-Majid A, Domingo L, Kutkat O, et al.
Int J Mol Sci . 2022 Oct; 23(19). PMID: 36233160
The search for an effective anti-viral to inhibit COVID-19 is a challenge for the specialized scientific research community. This work investigated the anti-coronavirus activity for spirooxindole-based phenylsulfone cycloadducts in a...
12.
Novel spirooxindole based benzimidazole scaffold: In vitro, nanoformulation and in vivo studies on anticancer and antimetastatic activity of breast adenocarcinoma
Barakat A, Alshahrani S, Al-Majid A, Alamary A, Haukka M, Abu-Serie M, et al.
Bioorg Chem . 2022 Sep; 129:106124. PMID: 36174446
The present work provided in vitro anticancer investigation of novel spirooxindole based benzimidazole scaffold SP1 and its nanoformulation with in vivo evaluation of anticancer and antimetastatic activity as potential drug...
13.
Mechanistic Evaluation of the Stability of Arylvinyl-1,2,4-trioxanes under Acidic Conditions for Their Oral Administration as an Antimalarial Drug
Kumari A, Karnatak M, Singh A, Hassam M, Rawat V, Islam M, et al.
ACS Omega . 2022 Jun; 7(21):17984-17994. PMID: 35664617
A mechanistic approach to understand the course of metabolism for synthetic 1,2,4-trioxanes, potent antimalarial compounds, to evaluate their bioavailability for antimalarial action has been studied in the present work. It...
14.
Substituted spirooxindole derivatives as potent anticancer agents through inhibition of phosphodiesterase 1
Barakat A, Islam M, Ghawas H, Al-Majid A, El-Senduny F, Badria F, et al.
RSC Adv . 2022 May; 8(26):14335-14346. PMID: 35540737
Spirooxindole is a promising chemo therapeutic agent. Possible targets include cancers of the liver, prostate, lung, stomach, colon, and breast. Here, we demonstrate a one-pot three-component reaction a [3 +...
15.
Cu(ii)-thiophene-2,5-bis(amino-alcohol) mediated asymmetric Aldol reaction and Domino Knoevenagel Michael cyclization: a new highly efficient Lewis acid catalyst
Al-Majid A, Alammari A, Alshahrani S, Haukka M, Islam M, Barakat A
RSC Adv . 2022 Apr; 12(10):6149-6165. PMID: 35424540
The highly efficient Lewis acid-catalytic system Cu(ii)-thiophene-2,5-bis(amino-alcohol) has been developed for enantioselective Aldol reaction of isatin derivatives with ketones. The new catalytic system also proved to be highly enantioselective for...
16.
Exploiting the Chiral Ligands of (imidazolinyl)- and (oxazolinyl)thiophenes-Synthesis and Application in Cu-Catalyzed Friedel-Crafts Asymmetric Alkylation
Islam M, Alammari A, Barakat A, Alshahrani S, Haukka M, Al-Majid A
Molecules . 2021 Dec; 26(23). PMID: 34885989
Five new -symmetric chiral ligands of 2,5-(imidazolinyl)thiophene () and 2,5-(oxazolinyl)thiophene ( and ) were synthesized from thiophene-2,5-dicarboxylic acid () with enantiopure amino alcohols (-) in excellent optical purity and chemical...
17.
Straightforward Regio- and Diastereoselective Synthesis, Molecular Structure, Intermolecular Interactions and Mechanistic Study of Spirooxindole-Engrafted Rhodanine Analogs
Barakat A, Haukka M, Soliman S, Ali M, Al-Majid A, El-Faham A, et al.
Molecules . 2021 Dec; 26(23). PMID: 34885853
Straightforward regio- and diastereoselective synthesis of bi-spirooxindole-engrafted rhodanine analogs - were achieved by one-pot multicomponent [3 + 2] cycloaddition (32CA) reaction of stabilized azomethine ylide (AYs -) generated in situ...
18.
Construction of Spirooxindole Analogues Engrafted with Indole and Pyrazole Scaffolds as Acetylcholinesterase Inhibitors
Islam M, Al-Majid A, Azam M, Verma V, Barakat A, Haukka M, et al.
ACS Omega . 2021 Dec; 6(47):31539-31556. PMID: 34869980
Twenty-five new hits of spirooxindole analogs engrafted with indole and pyrazole scaffolds were designed and constructed a [3+2]cycloaddition (32CA) reaction starting from three components: new chalcone-based indole and pyrazole scaffolds...
19.
Stereoselective Synthesis of the Di-Spirooxindole Analogs Based Oxindole and Cyclohexanone Moieties as Potential Anticancer Agents
Al-Majid A, Ali M, Islam M, Alshahrani S, Alamary A, Yousuf S, et al.
Molecules . 2021 Oct; 26(20). PMID: 34684885
A new series of di-spirooxindole analogs, engrafted with oxindole and cyclohexanone moieties, were synthesized. Initially, azomethine ylides were generated via reaction of the substituted isatins (isatin, , 6-chloroisatin, , 5-fluoroisatin,...
20.
Bimetallic Iron-Palladium Catalyst System as a Lewis-Acid for the Synthesis of Novel Pharmacophores Based Indole Scaffold as Anticancer Agents
Islam M, Ali M, Al-Majid A, Alamary A, Alshahrani S, Yousuf S, et al.
Molecules . 2021 Apr; 26(8). PMID: 33921334
The Friedel-Crafts reaction between substituted indoles as nucleophiles with chalcones-based benzofuran and benzothiophene scaffolds was carried out by employing a highly efficient bimetallic iron-palladium catalyst system. This catalytic approach produced...