Abdul R Khokhar
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Explore the profile of Abdul R Khokhar including associated specialties, affiliations and a list of published articles.
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9
Citations
199
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Recent Articles
1.
He G, Kuang J, Khokhar A, Siddik Z
Gynecol Oncol
. 2011 May;
122(2):402-9.
PMID: 21592546
Objective: Cisplatin is a DNA-damaging antitumor agent that is highly effective in treating ovarian cancer. It activates the p53/p21 pathway for its cytotoxic mode of action, but it does not...
2.
Lu C, Perez-Soler R, Piperdi B, Walsh G, Swisher S, Smythe W, et al.
J Clin Oncol
. 2005 May;
23(15):3495-501.
PMID: 15908659
Purpose: To determine pathologic response rates to liposome-entrapped cis-bisneodecanoato-trans-R,R-1,2-diaminocyclohexane platinum(II) (L-NDDP) administered intrapleurally in patients with malignant pleural mesothelioma. Patients And Methods: Thirty-three patients with malignant pleural mesothelioma and free-flowing...
3.
He G, Siddik Z, Huang Z, Wang R, Koomen J, Kobayashi R, et al.
Oncogene
. 2005 Mar;
24(18):2929-43.
PMID: 15735718
DNA damage often activates the p53-p21 pathway and causes G(1)-phase arrest in mammalian cells. Although there is ample evidence that p21 induction by p53 leads to Cdk2 inhibition, it is...
4.
Ali M, Khan S, Ojima H, Guzman I, Whitmire K, Siddik Z, et al.
J Inorg Biochem
. 2005 Feb;
99(3):795-804.
PMID: 15708801
A series of platinum(II) and (IV) monoadducts of the type [Pt(II)(DACH)LCl]NO3 and [Pt(IV)(DACH)trans-(X)2LCl]NO3 (where DACH=trans-1R,2R-diaminocyclohexane, L=adenine, guanine, hypoxanthine, cytosine, adenosine, guanosine, inosine, cytidine, 9-ethylguanine (9-EtGua), or 1-methylcytosine and X=hydroxo or...
5.
Mujoo K, Watanabe M, Khokhar A, Siddik Z
Prostate
. 2004 Sep;
62(1):91-100.
PMID: 15389812
Background: DACH-Ac-Pt [(1R,2R-diaminocyclohexane)-(trans-diacetato)-(dichloro)-platinum(IV)] is a novel cisplatin (CDDP) analog, and we have evaluated its potential activity in human prostate cancers. Methods: Cytotoxic, biochemical pharmacologic, cell cycle, and Western blot evaluations...
6.
Mujoo K, Watanabe M, Nakamura J, Khokhar A, Siddik Z
J Cancer Res Clin Oncol
. 2003 Sep;
129(12):709-18.
PMID: 14513366
Purpose: Resistance to chemotherapeutic drugs is a hallmark of many human cancers, which can occur independent of p53 gene status; however, the presence of wild-type p53 in chemorefractory tumors confers...
7.
Ali M, Khokhar A
J Inorg Biochem
. 2003 Sep;
96(4):452-6.
PMID: 13678810
A series of new platinum(II) and platinum(IV) adducts of type [P(II)(cis-1,4-DACH)LCl]NO(3,) where cis-1,4-DACH=cis-1,4-diaminocyclohexane, and L=9-ethylguanine, 1-methylcytosine, adenine, adenosine, cytosine, cytidine, guanine, and [Pt(IV)(cis-1,4-DACH)Ltrans-(X)(2)Cl]NO(3), (where Y=hydroxo or acetato), were synthesized and...
8.
Mukhopadhyay U, Thurston J, Whitmire K, Siddik Z, Khokhar A
J Inorg Biochem
. 2003 Mar;
94(1-2):179-85.
PMID: 12620689
A series of new platinum(II) complexes of the type [Pt(II)(mmap)X] (where mmap, 1-methyl-4-(methylamino)piperidine and X, 1,1-cyclobutanedicarboxylato (CBDCA), oxalato, malonato, methylmalonato, dimethylmalonato, ethylmalonato, diethylmalonato or 2,3-naphthalene dicarboxylato (NDCA)) have been synthesized...
9.
Shamsuddin S, van Hal J, Stark J, Whitmire K, Khokhar A
Inorg Chem
. 2001 Oct;
36(25):5969-5971.
PMID: 11670225
No abstract available.