Aarthi Ramakrishnan
Overview
Explore the profile of Aarthi Ramakrishnan including associated specialties, affiliations and a list of published articles.
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61
Citations
1176
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Recent Articles
1.
Zheng Q, Weekley B, Vinson D, Zhao S, Bastle R, Thompson R, et al.
Nature
. 2025 Jan;
637(8047):974-982.
PMID: 39779849
Histone H3 monoaminylations at Gln5 represent an important family of epigenetic marks in brain that have critical roles in permissive gene expression. We previously demonstrated that serotonylation and dopaminylation of...
2.
Mews P, Van der Zee Y, Gurung A, Estill M, Futamura R, Kronman H, et al.
Sci Adv
. 2024 Oct;
10(40):eado3514.
PMID: 39365860
A hallmark of addiction is the ability of drugs of abuse to trigger relapse after periods of prolonged abstinence. Here, we describe an epigenetic mechanism whereby chronic cocaine exposure causes...
3.
Chongtham A, Sharma A, Nath B, Murtha K, Gorbachev K, Ramakrishnan A, et al.
Exp Neurol
. 2024 Sep;
382:114967.
PMID: 39326823
It has been shown that excitotoxicity and tau-mediated toxicities are major contributing factors to neuronal death in Alzheimer's disease (AD). The excitatory amino acid transporter 2 (EAAT2 or GLT-1), the...
4.
Lee V, Tejero R, Silvia N, Sattiraju A, Ramakrishnan A, Shen L, et al.
bioRxiv
. 2024 Jul;
PMID: 39026692
Glioblastoma (GBM) is a lethal brain cancer with no effective treatment; understanding how GBM cells respond to tumor microenvironment remains challenging as conventional cell cultures lack proper cytoarchitecture while animal...
5.
Liu S, Muelken P, Maxim Z, Ramakrishnan A, Estill M, Lesage M, et al.
bioRxiv
. 2024 Jul;
PMID: 38979145
Opioid use disorder (OUD) is a neuropsychological disease that has a devastating impact on public health. Substantial individual differences in vulnerability exist, the neurobiological substrates of which remain unclear. To...
6.
Torres-Berrio A, Estill M, Patel V, Ramakrishnan A, Kronman H, Minier-Toribio A, et al.
Neuron
. 2024 Jul;
112(17):2973-2989.e10.
PMID: 38959894
Histone post-translational modifications are critical for mediating persistent alterations in gene expression. By combining unbiased proteomics profiling and genome-wide approaches, we uncovered a role for mono-methylation of lysine 27 at...
7.
Al-Kachak A, Di Salvo G, Fulton S, Chan J, Farrelly L, Lepack A, et al.
Nat Commun
. 2024 Jun;
15(1):5042.
PMID: 38871707
Mood disorders are an enigmatic class of debilitating illnesses that affect millions of individuals worldwide. While chronic stress clearly increases incidence levels of mood disorders, including major depressive disorder (MDD),...
8.
Teague C, Markovic T, Zhou X, Martinez-Rivera F, Minier-Toribio A, Zinsmaier A, et al.
J Neurosci
. 2024 Apr;
44(23).
PMID: 38637154
Cocaine use disorder is a significant public health issue without an effective pharmacological treatment. Successful treatments are hindered in part by an incomplete understanding of the molecular mechanisms that underlie...
9.
Serafini R, Ramakrishnan A, Shen L, Zachariou V
Neurobiol Pain
. 2024 Mar;
15:100153.
PMID: 38549875
Monoamine-targeting antidepressants serve as frontline medications for chronic pain and associated comorbidities. While persistent anti-allodynic properties of antidepressants generally require weeks of treatment, several groups have demonstrated acute analgesic effects...
10.
Marallano V, Ughetta M, Tejero R, Nanda S, Ramalingam R, Stalbow L, et al.
Sci Rep
. 2024 Mar;
14(1):7246.
PMID: 38538643
Glioblastoma (GBM) is the most common primary malignant cancer of the central nervous system. Insufficient oxygenation (hypoxia) has been linked to GBM invasion and aggression, leading to poor patient outcomes....