Aaron J Polichnowski
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Explore the profile of Aaron J Polichnowski including associated specialties, affiliations and a list of published articles.
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25
Citations
393
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Recent Articles
1.
Mannon E, Muller P, Sun J, Bush W, Coleman A, Ocasio H, et al.
Clin Sci (Lond)
. 2024 Feb;
138(4):189-203.
PMID: 38300615
Sodium bicarbonate (NaHCO3) is commonly utilized as a therapeutic to treat metabolic acidosis in people with chronic kidney disease (CKD). While increased dietary sodium chloride (NaCl) is known to promote...
2.
Alphonse S, Polichnowski A, Griffin K, Bidani A, Williamson G
Proc Eur Signal Process Conf EUSIPCO
. 2024 Jan;
2020:1165-1169.
PMID: 38288370
A convolutional deep neural network is employed to assess renal autoregulation using time series of arterial blood pressure and blood flow rate measurements in conscious rats. The network is trained...
3.
Chopde P, Alvarez-Cedron R, Alphonse S, Polichnowski A, Griffin K, Williamson G
Proc Eur Signal Process Conf EUSIPCO
. 2024 Jan;
2023:1145-1149.
PMID: 38162557
Different machine learning approaches for analyzing renal hemodynamics using time series of arterial blood pressure and renal blood flow rate measurements in conscious rats are developed and compared. Particular emphasis...
4.
Chivers J, Whiles S, Miles C, Biederman B, Ellison M, Lovingood C, et al.
Am J Physiol Renal Physiol
. 2022 Dec;
324(2):F193-F210.
PMID: 36475869
Chronic kidney disease (CKD) has a strong genetic component; however, the underlying pathways are not well understood. Dahl salt-sensitive (SS)/Jr rats spontaneously develop CKD with age and are used to...
5.
Potter J, Whiles S, Miles C, Whiles J, Mitchell M, Biederman B, et al.
J Am Heart Assoc
. 2021 Oct;
10(21):e020261.
PMID: 34689582
Background Abnormal renal hemodynamic responses to salt-loading are thought to contribute to salt-sensitive (SS) hypertension. However, this is based largely on studies in anesthetized animals, and little data are available...
6.
Mannon E, Sartain C, Wilkes T, Sun J, Polichnowski A, OConnor P
Am J Physiol Renal Physiol
. 2021 Aug;
321(4):F494-F504.
PMID: 34396787
Impairments in insulin sensitivity can occur in patients with chronic kidney disease (CKD). Correction of metabolic acidosis has been associated with improved insulin sensitivity in CKD, suggesting that metabolic acidosis...
7.
Polichnowski A, Williamson G, Blair T, Hoover D
Am J Physiol Regul Integr Comp Physiol
. 2021 Apr;
320(6):R871-R884.
PMID: 33851543
Donepezil is a centrally acting acetylcholinesterase (AChE) inhibitor with therapeutic potential in inflammatory diseases; however, the underlying autonomic and cholinergic mechanisms remain unclear. Here, we assessed effects of donepezil on...
8.
Crislip G, Patel B, Mohamed R, Ray S, Wei Q, Sun J, et al.
Am J Physiol Renal Physiol
. 2020 Jul;
319(3):F447-F457.
PMID: 32686518
Noninvasive determination of the severity of parenchymal injury in acute kidney injury remains challenging. Edema is an early pathological process following injury, which may correlate with changes in kidney volume....
9.
Polichnowski A, Griffin K, Licea-Vargas H, Lan R, Picken M, Long J, et al.
Am J Physiol Renal Physiol
. 2020 Mar;
318(5):F1086-F1099.
PMID: 32174143
Unilateral ischemia-reperfusion (UIR) injury leads to progressive renal atrophy and tubulointerstitial fibrosis (TIF) and is commonly used to investigate the pathogenesis of the acute kidney injury-chronic kidney disease transition. Although...
10.
Bidani A, Polichnowski A, Licea-Vargas H, Long J, Kliethermes S, Williamson G, et al.
J Am Soc Nephrol
. 2019 Dec;
31(2):324-336.
PMID: 31792155
Background: Renal autoregulation maintains stable renal function despite BP fluctuations and protects glomerular capillaries from hypertensive injury. However, real-time dynamics of renal autoregulation in conscious animals have not been characterized....