Aaron Gochman
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Explore the profile of Aaron Gochman including associated specialties, affiliations and a list of published articles.
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7
Citations
62
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Recent Articles
1.
Gochman A, Do T, Kim K, Schwarz J, Thorpe M, Blackwell D, et al.
Mol Pharmacol
. 2024 Jan;
105(3):194-201.
PMID: 38253398
Intracellular Ca leak from cardiac ryanodine receptor (RyR2) is an established mechanism of sudden cardiac death (SCD), whereby dysregulated Ca handling causes ventricular arrhythmias. We previously discovered the RyR2-selective inhibitor...
2.
Gochman A, Do T, Kim K, Schwarz J, Thorpe M, Blackwell D, et al.
bioRxiv
. 2023 Jul;
PMID: 37461611
Significance Statement: The cardiac ryanodine receptor (RyR2) is an untapped target in the stagnant field of antiarrhythmic drug development. We have confirmed RyR2 as an antiarrhythmic target in a mouse...
3.
Gochman A, Tan X, Bae C, Chen H, Swartz K, Jara-Oseguera A
Elife
. 2023 May;
12.
PMID: 37199723
The cation-permeable TRPV2 channel is important for cardiac and immune cell function. Cannabidiol (CBD), a non-psychoactive cannabinoid of clinical relevance, is one of the few molecules known to activate TRPV2....
4.
Blackwell D, Smith A, Do T, Gochman A, Schmeckpeper J, Hopkins C, et al.
J Pharmacol Exp Ther
. 2023 Mar;
385(3):205-213.
PMID: 36894328
The unnatural verticilide enantiomer (-verticilide) is a selective and potent inhibitor of cardiac ryanodine receptor (RyR2) calcium release channels and exhibits antiarrhythmic activity in a murine model of catecholaminergic polymorphic...
5.
Gochman A, Tan X, Bae C, Chen H, Swartz K, Jara-Oseguera A
bioRxiv
. 2023 Feb;
PMID: 36747846
The cation-permeable TRPV2 channel is essential for cardiac and immune cells. Cannabidiol (CBD), a non-psychoactive cannabinoid of clinical relevance, is one of the few molecules known to activate TRPV2. Using...
6.
Amin J, Gochman A, He M, Certain N, Wollmuth L
Neuron
. 2020 Dec;
109(3):488-501.e4.
PMID: 33264592
NMDA receptors (NMDARs) are glutamate-gated ion channels that mediate fast excitatory synaptic transmission in the nervous system. Applying glutamate to outside-out patches containing a single NMDAR, we find that agonist-bound...
7.
Amin J, Leng X, Gochman A, Zhou H, Wollmuth L
Nat Commun
. 2018 Sep;
9(1):3748.
PMID: 30217972
A variety of de novo and inherited missense mutations associated with neurological disorders are found in the NMDA receptor M4 transmembrane helices, which are peripheral to the pore domain in...