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Aaron D Springer

Explore the profile of Aaron D Springer including associated specialties, affiliations and a list of published articles. Areas
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Articles 5
Citations 333
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Recent Articles
1.
Springer A, Wang R, Wang J, Du Q, Pi W, Nguyen A, et al.
Cancer Res Commun . 2024 Sep; 4(10):2660-2672. PMID: 39292169
Treatment for patients with multiple myeloma has experienced rapid development and improvement in recent years; however, patients continue to experience relapse, and multiple myeloma remains largely incurable. B-cell maturation antigen...
2.
Huggins I, Medina C, Springer A, van den Berg A, Jadhav S, Cui X, et al.
Molecules . 2019 Sep; 24(18). PMID: 31509944
Nucleic Acid Therapeutics (NATs), including siRNAs and AntiSense Oligonucleotides (ASOs), have great potential to drug the undruggable genome. Targeting siRNAs and ASOs to specific cell types of interest has driven...
3.
Springer A, Dowdy S
Nucleic Acid Ther . 2018 May; 28(3):109-118. PMID: 29792572
Short-interfering RNA (siRNA)-induced RNAi responses have great potential to treat a wide variety of human diseases from cancer to pandemic viral outbreaks to Parkinson's Disease. However, before siRNAs can become...
4.
Kaulich M, Lee Y, Lonn P, Springer A, Meade B, Dowdy S
Nucleic Acids Res . 2015 Jan; 43(7):e45. PMID: 25586224
Gene knockout strategies, RNAi and rescue experiments are all employed to study mammalian gene function. However, the disadvantages of these approaches include: loss of function adaptation, reduced viability and gene...
5.
Meade B, Gogoi K, Hamil A, Palm-Apergi C, van den Berg A, Hagopian J, et al.
Nat Biotechnol . 2014 Nov; 32(12):1256-61. PMID: 25402614
RNA interference (RNAi) has great potential to treat human disease. However, in vivo delivery of short interfering RNAs (siRNAs), which are negatively charged double-stranded RNA macromolecules, remains a major hurdle....