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A SCRIABINE

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Citations 331
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Hoffman Jr F, Lenfers J, Niemers E, Pleiss U, SCRIABINE A, Janis R
Biochem Biophys Res Commun . 1993 Jan; 190(2):551-8. PMID: 8427598
The specific binding of a novel tritiated K+ channel opener, [3H]BAY X 9228, has been characterized in a rat insulinoma (RINm5F) cell line. The KD was 2.1 nM and Bmax...
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SCRIABINE A, Pan M, Vanhoutte P
Gen Pharmacol . 1990 Jan; 21(2):235-9. PMID: 2110088
1. The effects of nafazatrom, nordihydroguaiaretic acid (NDGA) and quercetin on Ca2(+)-induced vasoconstriction were studied in isolated rabbit ear arteries. 2. The arteries were perfused with Ca2(+)-free and high K+...
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SCRIABINE A, Schuurman T, Traber J
FASEB J . 1989 May; 3(7):1799-806. PMID: 2565839
Nimodipine, a Ca2+ antagonist with cerebrovasodilatory and anti-ischemic effects, binds to rat, guinea pig, and human brain membranes with high affinity (less than 1 nM). Only at higher concentrations has...
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SCRIABINE A, Kazda S
Magnesium . 1989 Jan; 8(5-6):253-65. PMID: 2693846
Many different classification systems for Ca2+ antagonists were proposed. They are mostly based on structural aspects or profiles of biological activity. 1,4-dihydropyridines, with Ca2+ channel antagonistic activity, including nifedipine and...
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Janis R, Shrikhande A, Johnson D, MCCARTHY R, Howard A, Greguski R, et al.
FEBS Lett . 1988 Nov; 239(2):233-6. PMID: 2846356
Bovine brain was subjected to acid extraction and several purification steps. A fraction from brain that eluted from C18 reverse-phase columns at 30-35% acetonitrile inhibited [3H]nitrendipine binding to cardiac membranes....
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Pan M, SCRIABINE A, STEINSLAND O
J Cardiovasc Pharmacol . 1988 Feb; 11(2):127-33. PMID: 2452304
BAY K 8644 at 6.25 nM to 1 microM enhanced, in a concentration-dependent manner, both phases of the vasoconstrictor response of the isolated perfused rabbit ear artery to electrical stimulation....
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SCRIABINE A, van den Kerckhoff W
Ann N Y Acad Sci . 1988 Jan; 522:698-706. PMID: 3288065
The major pharmacological findings with nimodipine reviewed in this chapter are summarized in TABLE 3. On the basis of these findings, the following conclusions appear to be justified: 1. Nimodipine...