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A Portner

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Articles 86
Citations 1854
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Recent Articles
1.
Alymova I, Taylor G, Portner A
Curr Drug Targets Infect Disord . 2006 Mar; 5(4):401-9. PMID: 16535861
The enzyme neuraminidase (NA) is an attractive target for antiviral strategy because of its essential role in the pathogenicity of many respiratory viruses. NA removes sialic acid from the surface...
2.
Takimoto T, Murti K, Bousse T, Scroggs R, Portner A
J Virol . 2001 Nov; 75(23):11384-91. PMID: 11689619
Paramyxoviruses are assembled at the surface of infected cells, where virions are formed by the process of budding. We investigated the roles of three Sendai virus (SV) membrane proteins in...
3.
Bousse T, Takimoto T, Matrosovich T, Portner A
Virology . 2001 May; 283(2):306-14. PMID: 11336555
The paramyxovirus P protein is an essential component of the viral RNA polymerase composed of P and L proteins. In this study, we characterized the physical and functional interactions between...
4.
Suzuki T, Portner A, Scroggs R, Uchikawa M, Koyama N, Matsuo K, et al.
J Virol . 2001 Apr; 75(10):4604-13. PMID: 11312330
Through their hemagglutinin-neuraminidase glycoprotein, parainfluenza viruses bind to sialic acid-containing glycoconjugates to initiate infection. Although the virus-receptor interaction is a key factor of infection, the exact nature of the receptors...
5.
Coronel E, Takimoto T, Murti K, Varich N, Portner A
J Virol . 2001 Jan; 75(3):1117-23. PMID: 11152484
The paramyxovirus nucleoproteins (NPs) encapsidate the genomic RNA into nucleocapsids, which are then incorporated into virus particles. We determined the protein-protein interaction between NP molecules and the molecular mechanism required...
6.
Takimoto T, Bousse T, Portner A
Virus Res . 2000 Nov; 70(1-2):45-53. PMID: 11074124
The large (L) protein, a subunit of paramyxovirus RNA polymerase complex is responsible for the majority of enzymic activities involved in viral replication and transcription. To gain insight of the...
7.
Crennell S, Takimoto T, Portner A, Taylor G
Nat Struct Biol . 2000 Nov; 7(11):1068-74. PMID: 11062565
Paramyxoviruses are the main cause of respiratory disease in children. One of two viral surface glycoproteins, the hemagglutinin-neuraminidase (HN), has several functions in addition to being the major surface antigen...
8.
Takimoto T, Taylor G, Crennell S, Scroggs R, Portner A
Virology . 2000 Apr; 270(1):208-14. PMID: 10772993
The hemagglutinin-neuraminidase (HN) glycoprotein of Newcastle disease virus was isolated by cleaving HN (cHN) from reconstituted virosome with chymotrypsin. N-terminal sequence analysis of the purified cHN showed that chymotrypsin cleavage...
9.
Coronel E, Murti K, Takimoto T, Portner A
J Virol . 1999 Jul; 73(8):7035-8. PMID: 10400805
The matrix (M) protein plays an essential role in the assembly and budding of some enveloped RNA viruses. We expressed the human parainfluenza virus type 1 (hPIV-1) M and/or NP...
10.
Takimoto T, Bousse T, Coronel E, Scroggs R, Portner A
J Virol . 1998 Nov; 72(12):9747-54. PMID: 9811709
In the assembly of paramyxoviruses, interactions between viral proteins are presumed to be specific. The focus of this study is to elucidate the protein-protein interactions during the final stage of...