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A Pejmun Haghighi

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Articles 18
Citations 1037
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Recent Articles
1.
Mori M, Rosko A, Farnsworth J, Carrasco G, Broomandkhoshbacht P, Pareja-Navarro K, et al.
eNeuro . 2024 Jan; 11(1). PMID: 38167616
We have developed an open-source software for neuroscientists to analyze electrophysiological recordings. Named SimplyFire, the software gives the users the flexibility to analyze a variety of recordings using an interactive...
2.
Aly A, Scott G, Calderon M, Pejmun Haghighi A
bioRxiv . 2022 Oct; PMID: 36299421
The coronavirus disease 2019 (COVID19) continues to spread despite global vaccination efforts (1). This, alongside the rapid emergence of vaccine resistant variants, creates a need for orthogonal therapeutic strategies targeting...
3.
Vuilleumier R, Miao M, Medina-Giro S, Ell C, Flibotte S, Lian T, et al.
Nucleic Acids Res . 2022 Aug; 50(17):9748-9764. PMID: 36029115
Retrograde bone morphogenetic protein (BMP) signaling at the Drosophila neuromuscular junction (NMJ) has served as a paradigm to study TGF-β-dependent synaptic function and maturation. Yet, how retrograde BMP signaling transcriptionally...
4.
Calderon M, Mori M, Kauwe G, Farnsworth J, Ulian-Benitez S, Maksoud E, et al.
Proc Natl Acad Sci U S A . 2022 Aug; 119(34):e2110097119. PMID: 35969789
While the role of barrier function in establishing a protective, nutrient-rich, and ionically balanced environment for neurons has been appreciated for some time, little is known about how signaling cues...
5.
Saviuk N, Chong Y, Wang P, Bermudez S, Zhao Z, Bhaskaran A, et al.
Cell Rep . 2022 Jun; 39(10):110911. PMID: 35675781
Genetic perturbances in translational regulation result in defects in cerebellar motor learning; however, little is known about the role of translational mechanisms in the regulation of cerebellar plasticity. We show...
6.
Maksoud E, Liao E, Pejmun Haghighi A
Cell Rep . 2019 Feb; 26(7):1774-1786.e4. PMID: 30759389
Pathogenic mutations in leucine-rich repeat kinase 2 (LRRK2) induce an age-dependent loss of dopaminergic (DA) neurons. We have identified Furin 1, a pro-protein convertase, as a translational target of LRRK2...
7.
Chong Y, Saviuk N, Pie B, Basisty N, Quinn R, Schilling B, et al.
Cell Rep . 2018 Apr; 23(1):11-22. PMID: 29617653
Throughout the developing nervous system, considerable synaptic re-organization takes place as postsynaptic neurons extend dendrites and incoming axons refine their synapses, strengthening some and eliminating others. It is well accepted...
8.
Liao E, Gray L, Tsurudome K, El-Mounzer W, Elazzouzi F, Baim C, et al.
PLoS Genet . 2018 Jan; 14(1):e1007184. PMID: 29373576
Retrograde signaling is essential for neuronal growth, function and survival; however, we know little about how signaling endosomes might be directed from synaptic terminals onto retrograde axonal pathways. We have...
9.
Kauwe G, Tsurudome K, Penney J, Mori M, Gray L, Calderon M, et al.
Neuron . 2016 Dec; 92(6):1204-1212. PMID: 27916456
While beneficial effects of fasting on organismal function and health are well appreciated, we know little about the molecular details of how fasting influences synaptic function and plasticity. Our genetic...
10.
Penney J, Tsurudome K, Liao E, Kauwe G, Gray L, Yanagiya A, et al.
Nat Commun . 2016 Jul; 7:12188. PMID: 27432119
Parkinson's disease gene leucine-rich repeat kinase 2 (LRRK2) has been implicated in a number of processes including the regulation of mitochondrial function, autophagy and endocytic dynamics; nevertheless, we know little...