A M Labhardt
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Explore the profile of A M Labhardt including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
314
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Recent Articles
1.
Klaus W, Grzesiek S, Labhardt A, Buchwald P, Hunziker W, Gross M, et al.
Eur J Biochem
. 1999 Jul;
262(3):933-8.
PMID: 10411658
Calbindin D28k, a member of the troponin C superfamily of calcium-binding proteins, contains six putative EF hand domains but binds only four calcium-atoms: one at a binding site of very...
2.
Klaus W, Gsell B, Labhardt A, Wipf B, Senn H
J Mol Biol
. 1998 Jan;
274(4):661-75.
PMID: 9417943
The solution structure of recombinant human interferon alpha-2a (Roferon-A) has been determined by multidimensional heteronuclear NMR spectroscopy. The calculations using simulated annealing produced a family of 24 convergent structures which...
3.
Altmann S, Labhardt A, Senn H, Wuthrich K
J Biomol NMR
. 1997 Jun;
9(4):445-6.
PMID: 9255948
No abstract available.
4.
Dale G, Broger C, Darcy A, Hartman P, DeHoogt R, Jolidon S, et al.
J Mol Biol
. 1997 Feb;
266(1):23-30.
PMID: 9054967
A single amino acid substitution, Phe98 to Tyr98, in dihydrofolate reductase (DHFR) is the molecular origin of trimethoprim (TMP) resistance in Staphylococcus aureus. This active site amino acid substitution was...
5.
Altmann S, Labhardt A, Bur D, Lehmann C, Bannwarth W, Billeter M, et al.
Nucleic Acids Res
. 1995 Dec;
23(23):4827-35.
PMID: 8532525
Molecular modelling studies resulted in the design of a variety of non-nucleotidic covalent linkers to bridge the 3'-end of the (+)-strand and the 5'-end of the (-)-strand in DNA duplexes....
6.
Kiefhaber T, Labhardt A, Baldwin R
Nature
. 1995 Jun;
375(6531):513-5.
PMID: 7777063
It is commonly believed that there are no detectable intermediates in the kinetic unfolding reactions of small proteins. If such intermediates could be found, they would give important information about...
7.
Grzesiek S, Dobeli H, Gentz R, Garotta G, Labhardt A, Bax A
Biochemistry
. 1992 Sep;
31(35):8180-90.
PMID: 1525157
1H, 13C, and 15N NMR assignments of the protein backbone of human interferon-gamma, a homodimer of 31.4 kDa, have been made using the recently introduced three-dimensional (3D) triple-resonance NMR techniques....
8.
Romagnoli P, Labhardt A, Sinigaglia F
EMBO J
. 1991 Jun;
10(6):1303-6.
PMID: 2026136
T cells generally recognize foreign antigens as peptides associated with self-molecules encoded by genes of the major histocompatibility complex (MHC). However, T cells which are specific for non-peptidic haptens have...
9.
Wyss D, Lahm H, Manneberg M, Labhardt A
J Antibiot (Tokyo)
. 1991 Feb;
44(2):172-80.
PMID: 1826288
Anantin, a naturally occurring peptide from Streptomyces coerulescens, binds competitively to the receptor of atrial natriuretic factor (ANF) from bovine adrenal cortex (Kd = 0.6 microM) and acts as ANF...
10.
Labhardt A, Wuthrich K
Eur J Biochem
. 1988 Nov;
177(2):295-305.
PMID: 2847926
Sequence-specific assignments are presented for the polypeptide backbone protons and a majority of the amino-acid-side-chain protons of alpha-neurotoxin from Dendroaspis polylepis polylepis, and individual amide proton-exchange rates with the solvent...