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A M Dempster

Explore the profile of A M Dempster including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 8
Citations 32
Followers 0
Related Specialties
Toxicology
General Medicine
Biology
Top 10 Co-Authors
C A SNYDER
H L Evans
D Panigrahi
D S Barrett
J P Kimball
C M Keenan
W J Powers
K E Blackman
E V Knight
B A Diwan
Published In
Arch Toxicol
Proc Soc Exp Biol Med
Toxicol Appl Pharmacol
Biotechnol Annu Rev
Neurobehav Toxicol Teratol
Affiliations
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Recent Articles
1.
Nonclinical safety evaluation of biotechnologically derived pharmaceuticals
Dempster A
Biotechnol Annu Rev . 2000 Jun; 5:221-58. PMID: 10875002
The primary objectives of nonclinical safety evaluation for pharmaceutical products are to identify potential target organ toxicity, provide a safe starting dose for clinical trials, and establish dose-response relationships. These...
2.
Preclinical toxicity evaluation of tepoxalin, a dual inhibitor of cyclooxygenase and 5-lipoxygenase, in Sprague-Dawley rats and beagle dogs
Knight E, Kimball J, Keenan C, Smith I, Wong F, Barrett D, et al.
Fundam Appl Toxicol . 1996 Sep; 33(1):38-48. PMID: 8812216
Tepoxalin [5- (4-chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-methyl-1H-pyrazole -3-propanamide] is an orally active anti-inflammatory agent, which inhibits both cyclooxygenase and 5-lipoxygenase activities. The oral toxicity of tepoxalin was evaluated in 1- and 6-month rat (up...
3.
Kinetics of granulocytic and erythroid progenitor cells are affected differently by short-term, low-level benzene exposure
Dempster A, SNYDER C
Arch Toxicol . 1991 Jan; 65(7):556-61. PMID: 1781737
In previous work, we determined that granulocytic (CFU-GM) and erythroid (CFU-E) progenitor cell populations exhibited disparate responses to short-term benzene exposures. We now report on work investigating possible mechanisms for...
4.
Short term benzene exposure provides a growth advantage for granulopoietic progenitor cells over erythroid progenitor cells
Dempster A, SNYDER C
Arch Toxicol . 1990 Jan; 64(7):539-44. PMID: 2073127
Because chronic benzene exposure is associated with acute myeloblastic leukemia and other myeloproliferative disorders, we sought to determine whether short-term benzene exposure provides a growth advantage for granulopoietic elements over...
5.
The ability of the murine erythron to respond to hemolytic doses of phenylhydrazine is significantly impaired by exposures to 10 ppm benzene
Dempster A, SNYDER C
Toxicol Lett . 1989 Sep; 48(3):249-57. PMID: 2781593
Male C57Bl mice were given 50 exposures (6 h/d x 5 d/wk x 10 wk) to 10 ppm benzene. At regular intervals during the course of the exposures, the numbers...
6.
The temporal relationship between behavioral and hematological effects of inhaled benzene
Dempster A, Evans H, SNYDER C
Toxicol Appl Pharmacol . 1984 Oct; 76(1):195-203. PMID: 6484989
The time-effect relationship of the behavioral and hematological changes caused by inhaled benzene was investigated in C57BL mice. Mice were exposed to air, or 100, 300, 1000, or 3000 ppm...
7.
Behavioral changes in mice following benzene inhalation
Evans H, Dempster A, SNYDER C
Neurobehav Toxicol Teratol . 1981 Jan; 3(4):481-5. PMID: 7335143
Although benzene is an important occupational health hazard and a carcinogen, the possibility that behavioral changes may forewarn of the later-occurring hematological changes has not been investigated. A time-sampling protocol...
8.
Effects of methylazoxymethanol acetate on inbred mice: influence of genetic factors on tumor induction
Diwan B, Dempster A, Blackman K
Proc Soc Exp Biol Med . 1979 Jul; 161(3):347-9. PMID: 461461
No abstract available.