A L Fluharty
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Explore the profile of A L Fluharty including associated specialties, affiliations and a list of published articles.
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97
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864
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Recent Articles
1.
Whitelegge J, Ahn V, Norris A, Sung H, Waring A, Stevens R, et al.
Cell Mol Biol (Noisy-le-grand)
. 2003 Oct;
49(5):799-807.
PMID: 14528917
Humans deficient in the cerebroside-sulfate activator protein (CSAct or Saposin B) are unable to catabolize sulfatide and other glycosphingolipids leading to their accumulation and neurodegenerative disease. Clinically this usually manifests...
2.
Zhong L, Manzi A, Skowronski E, Notterpek L, Fluharty A, Faull K, et al.
Cancer Res
. 2001 Aug;
61(15):5741-8.
PMID: 11479210
The cell surface molecules controlling apoptosis in cortical neurons are largely unknown. A monoclonal antibody was derived that induces cultured neocortical neurons to undergo apoptosis. A Fab fragment of the...
3.
Faull K, Johnson J, Kim M, To T, Whitelegge J, Stevens R, et al.
J Mass Spectrom
. 2001 Feb;
35(12):1416-24.
PMID: 11180632
The specific sugar residues and their linkages in the oligosaccharides from pig kidney and human urine cerebroside sulfate activator proteins (saposin B), although previously hypothesized, have been unambiguously characterized. Exhaustive...
4.
Fluharty C, Johnson J, Whitelegge J, Faull K, Fluharty A
J Neurosci Res
. 2001 Feb;
63(1):82-9.
PMID: 11169617
Cerebroside sulfate activator (saposin B) is a small protein involved in glycosphingolipid metabolism. It binds certain membrane lipids, making them available to water-soluble enzymes. Defects in this protein are responsible...
5.
Whitelegge J, Penn B, To T, Johnson J, Waring A, Sherman M, et al.
Protein Sci
. 2000 Oct;
9(9):1618-30.
PMID: 11045609
The cerebroside-sulfate activator protein (CSAct or Saposin B) is a small water-soluble glycoprotein that plays an essential role in the metabolism of certain glycosphingolipids, especially sulfatide. Deficiency of CSAct in...
6.
Faull K, Higginson J, Waring A, Johnson J, To T, Whitelegge J, et al.
Arch Biochem Biophys
. 2000 Apr;
376(2):266-74.
PMID: 10775412
Cerebroside sulfate activator (CSAct) protein is exceptionally resistant to heat denaturation and proteolytic digestion. Although water soluble the protein binds membrane-associated lipids. Its biological role is thought to be to...
7.
Faull K, Higginson J, Waring A, To T, Whitelegge J, Stevens R, et al.
J Mass Spectrom
. 2000 Apr;
35(3):392-401.
PMID: 10767769
Hydrogen-deuterium exchange can be a sensitive indicator of protein structural integrity. Comparisons were made between cerebroside sulfate activator protein (CSAct) in the native state and after treatment with guanidine hydrochloride...
8.
Marbois B, Faull K, Fluharty A, Rome L
Biochim Biophys Acta
. 2000 Feb;
1484(1):59-70.
PMID: 10685031
The accumulation of sulfatide (sulfatogalactosyl cerebroside) and changes in the sulfatide species present have been examined in the cerebellum of day 6-32 aged rats and in multiple sclerosis (MS) tissue...
9.
Fluharty A, Lombardo C, Louis A, Stevens R, Whitelegge J, Waring A, et al.
Mol Genet Metab
. 1999 Nov;
68(3):391-403.
PMID: 10562467
The purification of cerebroside sulfate activator (CSAct) or saposin B from pooled human urine is described. Urinary proteins are concentrated by ammonium sulfate precipitation. A suspension of the precipitate is...
10.
Faull K, Whitelegge J, Higginson J, To T, Johnson J, Krutchinsky A, et al.
J Mass Spectrom
. 1999 Oct;
34(10):1040-54.
PMID: 10510427
Cerebroside sulfate activator protein is a small, heat-stable protein that is exceptionally resistant to proteolytic attack. This protein is essential for the catabolism of cerebroside sulfate and several other glycosphingolipids....