A J F dApice
Overview
Explore the profile of A J F dApice including associated specialties, affiliations and a list of published articles.
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11
Citations
235
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Recent Articles
1.
Gock H, Lee K, Murray-Segal L, Mysore T, dApice A, Salvaris E, et al.
Transplant Proc
. 2016 Aug;
48(6):2200-7.
PMID: 27569971
Islet transplantation can potentially cure type 1 diabetes mellitus, but it is limited by a shortage of human donors as well as by islet graft destruction by inflammatory and thrombotic...
2.
Bas-Bernardet S, Tillou X, Branchereau J, Dilek N, Poirier N, Chatelais M, et al.
Am J Transplant
. 2015 Jan;
15(2):358-70.
PMID: 25612490
Galactosyl-transferase KO (GalT-KO) pigs represent a potential solution to xenograft rejection, particularly in the context of additional genetic modifications. We have performed life supporting kidney xenotransplantation into baboons utilizing GalT-KO...
3.
Hawthorne W, Salvaris E, Phillips P, Hawkes J, Liuwantara D, Burns H, et al.
Am J Transplant
. 2014 May;
14(6):1300-9.
PMID: 24842781
The instant blood-mediated inflammatory reaction (IBMIR) is a major obstacle to the engraftment of intraportal pig islet xenografts in primates. Higher expression of the galactose-α1,3-galactose (αGal) xenoantigen on neonatal islet...
4.
Gock H, Murray-Segal L, Winterhalter A, Aminian A, Moore G, Brown S, et al.
Am J Transplant
. 2014 Feb;
14(4):797-805.
PMID: 24502456
Differential protein glycosylation in the donor and recipient can have profound consequences for transplanted organs, as evident in ABO-incompatible transplantation and xenotransplantation. In this study, we investigated the impact of...
5.
Lee K, Lu B, Roussel J, Murray-Segal L, Salvaris E, Hodgkinson S, et al.
Am J Transplant
. 2012 Jun;
12(9):2363-72.
PMID: 22681753
Thrombosis and inflammation are major obstacles to successful pig-to-human solid organ xenotransplantation. A potential solution is genetic modification of the donor pig to overexpress molecules such as the endothelial protein...
6.
Bas-Bernardet S, Tillou X, Poirier N, Dilek N, Chatelais M, Devalliere J, et al.
Transplant Proc
. 2011 Nov;
43(9):3426-30.
PMID: 22099813
Galactosyl-transferase knockout (GT-KO) pigs represent the latest major progress to reduce immune reactions in xenotransplantation. However, their organs are still subject to rapid humoral rejection involving complement activation requiring the...
7.
Mital R, Zhang W, Cai M, Huttinger Z, Goodman L, Wheeler D, et al.
Am J Physiol Heart Circ Physiol
. 2011 Feb;
300(5):H1960-70.
PMID: 21335461
Antioxidant enzymatic pathways form a critical network that detoxifies ROS in response to myocardial stress or injury. Genetic alteration of the expression levels of individual enzymes has yielded mixed results...
8.
Crikis S, Lu B, Murray-Segal L, Selan C, Robson S, dApice A, et al.
Am J Transplant
. 2010 Sep;
10(12):2586-95.
PMID: 20840479
The vascular ectonucleotidases CD39[ENTPD1 (ectonucleoside triphosphate diphosphohydrolase-1), EC 3.6.1.5] and CD73[EC 3.1.3.5] generate adenosine from extracellular nucleotides. CD39 activity is critical in determining the response to ischemia-reperfusion injury (IRI), and...
9.
Anti-inflammatory and anticoagulant effects of transgenic expression of human thrombomodulin in mice
Crikis S, Zhang X, Dezfouli S, Dwyer K, Murray-Segal L, Salvaris E, et al.
Am J Transplant
. 2010 Jan;
10(2):242-50.
PMID: 20055798
Thrombomodulin (TBM) is an important vascular anticoagulant that has species specific effects. When expressed as a transgene in pigs, human (h)TBM might abrogate thrombotic manifestations of acute vascular rejection (AVR)...
10.
Roussel J, Moran C, Salvaris E, Nandurkar H, dApice A, Cowan P
Am J Transplant
. 2008 May;
8(6):1101-12.
PMID: 18444940
Incompatibility between pig thrombomodulin (TM) and primate thrombin is thought to be an important factor in the development of microvascular thrombosis in rejecting pig-to-primate xenografts. To examine this interaction at...