A H Beesley
Overview
Explore the profile of A H Beesley including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
285
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0
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Recent Articles
1.
Stirnweiss A, McCarthy K, Oommen J, Crook M, Hardy K, Kees U, et al.
Oncogenesis
. 2015 Nov;
4:e174.
PMID: 26551281
NUT midline carcinoma (NMC) is a fatal cancer that arises in various tissues along the upper midline of the body. The defining molecular feature of NMC is a chromosomal translocation...
2.
Samuels A, Beesley A, Yadav B, Papa R, Sutton R, Anderson D, et al.
Blood Cancer J
. 2014 Aug;
4:e232.
PMID: 25083816
Relapse and acquired drug resistance in T-cell acute lymphoblastic leukemia (T-ALL) remains a significant clinical problem. This study was designed to establish a preclinical model of resistance to induction therapy...
3.
Beesley A, Stirnweiss A, Ferrari E, Endersby R, Howlett M, Failes T, et al.
Br J Cancer
. 2014 Feb;
110(5):1189-98.
PMID: 24518598
Background: The NUT midline carcinoma (NMC) is a rare but fatal cancer for which systematic testing of therapy options has never been performed. Methods: On the basis of disease biology,...
4.
Thompson-Wicking K, Francis R, Stirnweiss A, Ferrari E, Welch M, Baker E, et al.
Oncogene
. 2012 Nov;
32(39):4664-74.
PMID: 23128391
Nuclear protein in testis (NUT)-midline carcinoma (NMC) is a rare, aggressive disease typically presenting with a single t(15;19) translocation that results in the generation of a bromodomain-containing protein 4 (BRD4)-NUT...
5.
Beesley A, Firth M, Ford J, Weller R, Freitas J, Perera K, et al.
Br J Cancer
. 2009 May;
100(12):1926-36.
PMID: 19436302
Glucocorticoids (GCs) are among the most important drugs for acute lymphoblastic leukaemia (ALL), yet despite their clinical importance, the exact mechanisms involved in GC cytotoxicity and the development of resistance...
6.
Beesley A, Palmer M, Ford J, Weller R, Cummings A, Freitas J, et al.
Br J Cancer
. 2006 Nov;
95(11):1537-44.
PMID: 17117183
Cell lines are important models for drug resistance in acute lymphoblastic leukaemia (ALL), but are often criticised as being unrepresentative of primary disease. There are also doubts regarding the authenticity...
7.
Boag J, Beesley A, Firth M, Freitas J, Ford J, Hoffmann K, et al.
Leukemia
. 2006 Oct;
20(10):1731-7.
PMID: 17041637
The cells of solid tumours are known to have an altered metabolism, with high rates of glucose uptake and glycolysis, which results in the excessive production of lactate. To date...
8.
Ortega B, Beesley A, Hornby D, White S
Biochem Biophys Res Commun
. 2000 Oct;
277(1):147-51.
PMID: 11027655
Potassium secretion by the kidney is vital for the maintenance of K(+) homeostasis. RACTK1, a putative inwardly rectifying potassium channel cloned from cultured rabbit collecting duct cells, has been proposed...
9.
Ortega B, Millar I, Beesley A, Robson L, White S
J Physiol
. 2000 Oct;
528 Pt 1:5-13.
PMID: 11018101
1. The family of Kir1.1 (ROMK) channel proteins constitute a secretory pathway for potassium in principal cells of cortical collecting duct and thick ascending limb of Henle's loop. Mutations in...
10.
Kunzelmann K, Beesley A, King N, Karupiah G, Young J, Cook D
Proc Natl Acad Sci U S A
. 2000 Aug;
97(18):10282-7.
PMID: 10920189
Many pathogens causing diarrhea do so by modulating ion transport in the gut. Respiratory pathogens are similarly associated with disturbances of fluid balance in the respiratory tract, although it is...