A B Chen
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Explore the profile of A B Chen including associated specialties, affiliations and a list of published articles.
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44
Citations
512
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Recent Articles
1.
Zeng G, Chen A, Li W, Song J, Gao C
Genet Mol Res
. 2015 Nov;
14(4):14811-22.
PMID: 26600542
Our study examined the relationship between the expression of matrix metalloproteinases (MMP)-1, MMP-2, and MMP-9 proteins and the pathogenesis of osteoarthritis (OA). We employed rigorous inclusion and exclusion criteria in...
2.
Su H, Hsu R, Chen A, Wang Y, Hsiao W, Lai W, et al.
Nature
. 2003 Jun;
423(6943):974-6.
PMID: 12827198
Transient luminous events in the atmosphere, such as lighting-induced sprites and upwardly discharging blue jets, were discovered recently in the region between thunderclouds and the ionosphere. In the conventional picture,...
3.
Harris R, Kabakoff B, Macchi F, Shen F, Kwong M, Andya J, et al.
J Chromatogr B Biomed Sci Appl
. 2001 Mar;
752(2):233-45.
PMID: 11270864
Seven forms of a therapeutic recombinant antibody that binds to the her2/neu gene product were resolved by cation-exchange chromatography. Structural differences were assigned by peptide mapping and HIC after papain...
4.
Felten C, Quan C, Chen A, McNerney T, Goetzinger W, Karger B
J Chromatogr A
. 1999 Sep;
853(1-2):295-308.
PMID: 10486737
This paper describes the analysis of recombinant human deoxyribonuclease (rhDNAse), an acidic and complex phosphoglycoprotein, by capillary zone electrophoresis (CZE). Separation performance was found to be dramatically improved by the...
5.
Hunt G, Hotaling T, Chen A
J Chromatogr A
. 1998 Apr;
800(2):355-67.
PMID: 9561769
A capillary isoelectric focusing (cIEF) method has been developed for the purpose of determining the identity and charge distribution of mouse/human chimeric antibody to human CD20 antigen (C2B8). The assay...
6.
Ralph P, Ryskamp T, Chen A, Mukku V
J Immunol Methods
. 1997 Mar;
202(2):163-71.
PMID: 9107305
A simple and non-radioactive complement-dependent cytotoxicity assay was developed to determine the relative potency of an anti-CD20 mAb, IDEC-C2B8. The assay measures the relative number of viable cells based on...
7.
Hunt G, Moorhouse K, Chen A
J Chromatogr A
. 1996 Sep;
744(1-2):295-301.
PMID: 8843678
Capillary isoelectric focusing (cIEF) and IEF of recombinant humanized monoclonal antibody HER2 (rhuMAbHER2) show five charged isoforms with estimated pI values ranging from 8.6-9.1. The cIEF assay demonstrated good precision...
8.
Chen A, Rickel C, Flanigan A, Hunt G, Moorhouse K
J Chromatogr A
. 1996 Sep;
744(1-2):279-84.
PMID: 8843676
Four commercial ampholytes: Ampholine and Pharmalyte (Pharmacia Biotech), Bio-Lyte (Bio-Rad) and Servalyt (Serva) were evaluated for their ability to resolve recombinant tissue-type plasminogen activator (rt-PA) glycoforms by isoelectric focusing (IEF)...
9.
Thorne J, Goetzinger W, Chen A, Moorhouse K, Karger B
J Chromatogr A
. 1996 Sep;
744(1-2):155-65.
PMID: 8843664
The microscale techniques of CZE, cIEF and SDS capillary electrophoresis have been evaluated for the analysis of a complex glycoprotein, recombinant tissue plasminogen activator (rtPA). A series of omega-amino acid...
10.
Roswall E, Mukku V, Chen A, Hoff E, Chu H, McKay P, et al.
Biologicals
. 1996 Mar;
24(1):25-39.
PMID: 8733599
Two methods, High-Performance Receptor Binding Chromatography (HPRBC) and Cell Proliferation (CP), have been developed as alternatives to the classical hypophysectomized rat weight gain bioassay for the determination of potency for...