Cell Reactions Following Acute Brain Injury: a Review

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 1999 Feb 11

PMID 9972867

Citations 18

Authors

W T Norton

Affiliations

Soon will be listed here.

Abstract

The proliferative behavior of glia following a cerebral stab wound in adult rats is reviewed. Proliferation was determined by both PCNA and [3H]thymidine labeling. Microglia were the first cells to divide and constituted the bulk of dividing cells. Both ramified and ameboid microglia divided. A smaller number of astrocytes entered the cell cycle a day later and were shown to derive from differentiated reactive cells. No differentiated oligodendroglia were labeled by thymidine, although a small number of dividing immature oligodendroglia could be detected in cultures of cells labeled in vivo. Recent studies of the properties of oligodendroglial precursors in brain repair mechanisms are discussed. The results so far support our conclusion that differentiated oligodendrocytes do not divide.

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