Effects of Acute Morphine Administration on the Catecholamine Metabolism of Three Strains of Mice

Overview

Journal Psychopharmacol Commun

Specialty Pharmacology

Date 1976 Jan 1

PMID 996278

Citations 5

Authors

E Kempf

M Gill

G Mack

P Mandel

Affiliations

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Abstract

Inbred mouse strains exhibit differences in motor activity and brain catecholamine metabolism after acute morphine injection. The two strains C57BL/6J and Balb/cJ, which increased motor activity after morphine present also an increased noradrenaline turnover in the pons medulla, whereas no difference were found in the DBA/2J strain whose motor activity was unchanged. A correlation seems to exist between motor activity and the noradrenaline metabolism in the brain stem.

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