Functional and Morphologic Maturation of Superficial and Juxtamedullary Nephrons in the Rat

Overview

Journal J Physiol

Specialty Physiology

Date 1976 Oct 1

PMID 994033

Citations 4

Authors

C de Rouffignac

L Monnens

Affiliations

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Abstract

The development of single nephron glomerular filtration rate (SNGFER) was studied in both superficial and juxtamedullary nephrons in rats in relation to concomitant morphologic maturation. These experiments were carried out in rats between 23 and 91 days of age (between 36 nad 275 g body weight) with the [14C]ferrocyanide infusion technique. 2. SNGFR of the superficial and juxtamedullary nephrons increased with body weight, glomerular volume and proximal tubular length. 3. The ratio SNGFR of the superficial (S) nephrons/SNGFR of the juxtamedullary (JM) nephrons rose from 0-60 in the 40-60 g rats to 0-84 in the adult rats, demonstrating the centrifugal functional maturation of the nephrons. 4. The S/JM ratio for both glomerular volume and tubular length was constant and averaged 0-72+/--0-12 and 0-81+/-0-05, respectively, indicating that while the increase in SNGFR was greater for S than for JM nephrons, this was not accompanied by concomitant disproportionate increases of glomerular volume and/or proximal tubular length between these nephron categories during development in the rat.

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References

Aperia A, Herin P . Development of glomerular perfusion rate and nephron filtration rate in rats 17-60 days old. Am J Physiol. 1975; 228(5):1319-25. DOI: 10.1152/ajplegacy.1975.228.5.1319. View

Goncharevskaya O, DLOUHA H . The development of various generations of nephrons during postnatal ontogenesis in the rat. Anat Rec. 1975; 182(3):367-75. DOI: 10.1002/ar.1091820310. View

DAMADIAN R, SHWAYRI E, Bricker N . ON THE EXISTENCE OF NON-URINE FORMING NEPHRONS IN THE DISEASED KIDNEY OF THE DOG. J Lab Clin Med. 1965; 65:26-39. View

BAXTER J, YOFFEY J . The post-natal development of renal tubules in the rat. J Anat. 1948; 82(Pt 4):189-97. PMC: 1273064. View

Jamison R . Evidence for functional intrarenal heterogeneity obtained by the micropuncture technique. Yale J Biol Med. 1972; 45(3-4):254-62. PMC: 2591969. View

Deen W, ROBERTSON C, Brenner B . A model of glomerular ultrafiltration in the rat. Am J Physiol. 1972; 223(5):1178-83. DOI: 10.1152/ajplegacy.1972.223.5.1178. View

Brenner B, Troy J, Daugharty T, Deen W, ROBERTSON C . Dynamics of glomerular ultrafiltration in the rat. II. Plasma-flow dependence of GFR. Am J Physiol. 1972; 223(5):1184-90. DOI: 10.1152/ajplegacy.1972.223.5.1184. View

Bonvalet J, Champion M, Wanstok F, BERJAL G . Compensatory renal hypertrophy in young rats: Increase in the number of nephrons. Kidney Int. 1972; 1(6):391-6. DOI: 10.1038/ki.1972.51. View

Kleinman L, Reuter J . Maturation of glomerular blood flow distribution in the new-born dog. J Physiol. 1973; 228(1):91-103. PMC: 1331228. DOI: 10.1113/jphysiol.1973.sp010074. View

10.

Deen W, Troy J, ROBERTSON C, Brenner B . Dynamics of glomerular ultrafiltration in the rat. IV. Determination of the ultrafiltration coefficient. J Clin Invest. 1973; 52(6):1500-8. PMC: 302415. DOI: 10.1172/JCI107324. View

11.

OLBING H, BLAUFOX M, Aschinberg L, Silkalns G, Bernstein J, Spitzer A . Postnatal changes in renal glomerular blood flow distribution in puppies. J Clin Invest. 1973; 52(11):2885-95. PMC: 302557. DOI: 10.1172/JCI107485. View

12.

Spitzer A, Brandis M . Functional and morphologic maturation of the superficial nephrons. Relationship to total kidney function. J Clin Invest. 1974; 53(1):279-87. PMC: 301463. DOI: 10.1172/JCI107548. View

13.

Chabardes D, Poujeol P, Deiss S, Bonvalet J, de Rouffignac C . Intrarenal glomerular filtration rate distribution in salt loaded rats. A study of different techniques using ferrocyanide ions. Pflugers Arch. 1974; 349(3):191-202. DOI: 10.1007/BF00592447. View

14.

Bonvalet J, Bencsath P, de Rouffignac C . Glomerular filtration rate of superficial and deep nephrons during aortic constriction. Am J Physiol. 1972; 222(3):599-606. DOI: 10.1152/ajplegacy.1972.222.3.599. View

15.

COELHO J, CHIEN K, Bradley S . Measurement of single-nephron glomerular filtration rate without micropuncture. Am J Physiol. 1972; 223(4):832-9. DOI: 10.1152/ajplegacy.1972.223.4.832. View

16.

Spitzer A, EDELMANN Jr C . Maturational changes in pressure gradients for glomerular filtration. Am J Physiol. 1971; 221(5):1431-5. DOI: 10.1152/ajplegacy.1971.221.5.1431. View

17.

Jose P, Logan A, SLOTKOFF L, LILIENFIELD L, CALCAGNO P, Eisner G . Intrarenal blood flow distribution in canine puppies. Pediatr Res. 1971; 5(8):335-44. DOI: 10.1203/00006450-197108000-00001. View

18.

Horster M, Lewy J . Filtration fraction and extraction of PAH during neonatal period in the rat. Am J Physiol. 1970; 219(4):1061-5. DOI: 10.1152/ajplegacy.1970.219.4.1061. View

19.

de Rouffignac C, Deiss S, Bonvalet J . [Determination of the glomerular filtration rate of individual nephrons accessible and inaccessible to micropuncture]. Pflugers Arch. 1970; 315(4):273-90. DOI: 10.1007/BF00593456. View

20.

de Rouffignac C, Bonvalet J . [Study of variations in the glomerular filtration rate of single superficial and deep nephrons as a function of sodium intake in the rat]. Pflugers Arch. 1970; 317(2):141-56. DOI: 10.1007/BF00592498. View