The Effects of AMP on the Potential of Rat Cerebral Cortical Neurones

Overview

Journal Can J Physiol Pharmacol

Specialties Pharmacology
Physiology

Date 1976 Oct 1

PMID 991006

Citations 4

Authors

J P Edstrom

J W Phillis

Affiliations

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Abstract

Intracellular recordings have shown that AMP, applied extracellularly, consistently produces a hyperpolarization in the absence of any pronounced alterations in membrane conductance and causes a reduction in spontaneously occurring and evoked postsynaptic potentials. Potential mechanisms of action of AMP are discussed, including the possibility that it may depress transmitter release from presynaptic nerve terminals.

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