Calcitonin and Histaminase in C-cell Hyperplasia and Medullary Thyroid Carcinoma. A Light Microscopic and Immunohistochemical Study

Overview

Journal Am J Pathol

Publisher Elsevier

Specialty Pathology

Date 1978 Jul 1

PMID 99045

Citations 5

Authors

G Mendelsohn

J C Eggleston

W R Weisburger

D S GANN

S B Baylin

Affiliations

Soon will be listed here.

Abstract

The thyroid glands of 13 patients with gross medullary thyroid carcinoma (4 sporadic, 9 familial), 3 patients with clinically occult microscopic carcinoma, and 5 patients with C-cell hyperplasia have been studied using routine light microscopy and immunohistochemical techniques. The morphologic features of the spectrum of C-cell proliferative lesions are reviewed, and the distribution of calcitonin and histaminase in these lesions is compared. Calcitonin production is a property of normal, hyperplastic, and neoplastic C cells, and the hormone is present in the majority of tumor cells in medullary carcinoma. In contrast, histaminase is shown to be present only in some cells in medullary carcinoma and not in normal or hyperplastic C cells. We believe that the presence of histaminase in a C-cell proliferative lesion is an atypical phenomenon and indicative of malignancy.

Citing Articles

Thyroid venous catheterization in the early diagnosis of familial medullary thyroid carcinoma.

Wells Jr S, Baylin S, Johnsrude I, Harrington D, Mendelsohn G, Ontjes D Ann Surg. 1982; 196(5):505-11.

PMID: 7125737 PMC: 1352780. DOI: 10.1097/00000658-198211000-00001.

The importance of early diagnosis in patients with hereditary medullary thyroid carcinoma.

Wells Jr S, Baylin S, Leight G, DALE J, Dilley W, Farndon J Ann Surg. 1982; 195(5):595-9.

PMID: 7073356 PMC: 1352565. DOI: 10.1097/00000658-198205000-00008.

Calcitonin-like immunoreactivity of amyloid fibrils in medullary thyroid carcinomas. An immunoelectron microscope study.

Berger G, Berger N, GUILLAUD M, Trouillas J, VAUZELLE J Virchows Arch A Pathol Anat Histopathol. 1988; 412(6):543-51.

PMID: 3129866 DOI: 10.1007/BF00844290.

Ultrastructural and electron immunohistochemical features of medullary thyroid carcinoma.

Holm R, Farrants G, Nesland J, Sobrinho-Simoes M, Jorgensen O, JOHANNESSEN J Virchows Arch A Pathol Anat Histopathol. 1989; 414(5):375-84.

PMID: 2499093 DOI: 10.1007/BF00718620.

Distribution of beta-endorphin immunoreactivity in normal human pituitary.

Mendelsohn G, DAgostino R, Eggleston J, Baylin S J Clin Invest. 1979; 63(6):1297-301.

PMID: 221539 PMC: 372078. DOI: 10.1172/JCI109424.

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