Platinum Nephrotoxicity

Overview

Journal Am J Med

Specialty General Medicine

Date 1978 Aug 1

PMID 99034

Citations 112

Authors

N E Madias

J T Harrington

Affiliations

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Abstract

Platinum coordination complexes have recently been introduced in cancer chemotherapy with considerable success. However, significant nephrotoxicity has emerged as a factor that limits the therapeutic usefulness of these compounds. In this article we review the available knowledge on platinum nephrotoxicity and its prevention that has been derived from both toxicologic studies in animals and clinical trials in human subjects.

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