The Stereochemical Configuration of Lysobisphosphatidic Acid from Rat Liver, Rabbit Lung and Pig Lung

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 1976 Nov 19

PMID 990300

Citations 10

Authors

A Joutti

J Brotherus

O Renkonen

R Laine

W Fischer

Affiliations

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Abstract

Lysobisphosphatidic acid known also as bis(monoacyl-glycerol)phosphate, was isolated from liver of rats treated with Triton WR1339, and from rabbit and pig lung. Alkaline hydrolysates of all these samples of lysobisphosphatidic acid were essentially similar and contained phosphorus, total glycerol, free glycerol, total glycerophosphates, beta-glycerophosphate, total alpha-glycerophosphates, sn-glycero-1-phosphate and sn-glycero-3-phosphate in a molar ratio of 1.0 : 2.0 : 1.0 : 1.0 :0.6 : 0.4 : 0.38 : 0.04. This proves that the backbone of the principal lysobisphosphatidic acid from all three sources has the structure of 1-sn-glycerophospho-1-sn-glycerol.

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