Virocrine Transformation: the Intersection Between Viral Transforming Proteins and Cellular Signal Transduction Pathways

Overview

Journal Annu Rev Microbiol

Publisher Annual Reviews

Specialty Microbiology

Date 1999 Jan 19

PMID 9891803

Citations 6

Authors

D DiMaio

C C Lai

O Klein

Affiliations

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Abstract

This review describes a mechanism of viral transformation involving activation of cellular signaling pathways. We focus on four viral oncoproteins: the E5 protein of bovine papillomavirus, which activates the platelet-derived growth factor beta receptor; gp55 of spleen focus forming virus, which activates the erythropoietin receptor; polyoma virus middle T antigen, which resembles an activated receptor tyrosine kinase; and LMP-1 of Epstein-Barr virus, which mimics an activated tumor necrosis factor receptor. These examples indicate that diverse viruses induce cell transformation by activating cellular signal transduction pathways. Study of this mechanism of viral transformation will provide new insights into viral tumorigenesis and cellular signal transduction.

Citing Articles

Physical and functional interaction between polyoma virus middle T antigen and insulin and IGF-I receptors is required for oncogene activation and tumour initiation.

Novosyadlyy R, Vijayakumar A, Lann D, Fierz Y, Kurshan N, LeRoith D Oncogene. 2009; 28(39):3477-86.

PMID: 19617901 PMC: 2756316. DOI: 10.1038/onc.2009.209.

In vitro dimerization of the bovine papillomavirus E5 protein transmembrane domain.

Oates J, Hicks M, Dafforn T, DiMaio D, Dixon A Biochemistry. 2008; 47(34):8985-92.

PMID: 18672907 PMC: 3711124. DOI: 10.1021/bi8006252.

Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase.

He Y, Nakao H, Tan S, Polyak S, Neddermann P, Vijaysri S J Virol. 2002; 76(18):9207-17.

PMID: 12186904 PMC: 136456. DOI: 10.1128/jvi.76.18.9207-9217.2002.

Middle T antigen activation of signal transduction pathways does not overcome p53-mediated growth arrest.

Doherty J, Freund R J Virol. 1999; 73(9):7882-5.

PMID: 10438885 PMC: 104322. DOI: 10.1128/JVI.73.9.7882-7885.1999.

A lysine-to-arginine change found in natural alleles of the human T-cell lymphotropic/leukemia virus type 1 p12(I) protein greatly influences its stability.

Trovato R, Mulloy J, Johnson J, Takemoto S, de Oliveira M, Franchini G J Virol. 1999; 73(8):6460-7.

PMID: 10400740 PMC: 112727. DOI: 10.1128/JVI.73.8.6460-6467.1999.