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Monoclonal Antibody-resistant Mutants Selected with a Respiratory Syncytial Virus-neutralizing Human Antibody Fab Fragment (Fab 19) Define a Unique Epitope on the Fusion (F) Glycoprotein

Overview
Journal Virology
Specialty Microbiology
Date 1999 Jan 8
PMID 9878616
Citations 26
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Abstract

A recombinant human antibody fragment, designated RSV Fab 19, efficiently neutralizes respiratory syncytial virus (RSV). Here we report the results of our sequence analysis of antibody escape mutants that identified F glycoprotein amino acids critical for binding of human or murine RSV F-neutralizing antibodies.

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