Systematic Review of the Treatment of Upper Respiratory Tract Infection

Overview

Journal Arch Dis Child

Specialty Pediatrics

Date 1999 Jan 6

PMID 9875017

Citations 48

Authors

T Fahey

N Stocks

T Thomas

Affiliations

Soon will be listed here.

Abstract

Objectives: To assess the risks and benefits of antibiotic treatment in children with symptoms of upper respiratory tract infection (URTI).

Design: Quantitative systematic review of randomised trials that compare antibiotic treatment with placebo.

Data Sources: Twelve trials retrieved from a systematic search (electronic databases, contact with authors, contact with drug manufacturers, reference lists); no restriction on language.

Main Outcome Measures: The proportion of children in whom the clinical outcome was worse or unchanged; the proportion of children who suffered complications or progression of illness; the proportion of children who had side effects.

Results: 1699 children were randomised in six trials that contributed to the meta-analysis. Six trials were not used in the meta-analysis because of different outcomes or incomplete data. Clinical outcome was not improved by antibiotic treatment (relative risk 1.01, 95% confidence interval (CI) 0.90 to 1.13), neither was the proportion of children suffering from complications or progression of illness (relative risk 0.71, 95% CI 0.45 to 1.12). Complications from URTI in the five trials that reported this outcome was low (range 2-15%). Antibiotic treatment was not associated with an increase in side effects compared with placebo (relative risk 0.8, 95% CI 0.54 to 1.21).

Conclusions: In view of the lack of efficacy and low complication rates, antibiotic treatment of children with URTI is not supported by current evidence from randomised trials.

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