Clinical Islet Cell Transplantation. Are We There Yet?

Overview

Journal Int J Pancreatol

Specialty Gastroenterology

Date 1999 Jan 5

PMID 9873950

Citations 2

Authors

L Rosenberg

Affiliations

Soon will be listed here.

Abstract

Diabetes mellitus is perhaps the most devastating chronic disease of all time. A brief history of the evolution of treatment modalities is provided, culminating in the rationale for the physiologic replacement of a functioning beta-cell mass by transplantation. Vascularized pancreas transplantation is discussed briefly as an introduction to the transplantation of the isolated islet. A detailed review of the current state of human islet transplantation for the cure of diabetes is then described. Finally, areas for future development are highlighted.

Citing Articles

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Modulation of JNK and p38 stress activated protein kinases in isolated islets of Langerhans: insulin as an autocrine survival signal.

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References

Ekstrand A, Eriksson J, Gronhagen-Riska C, Ahonen P, Groop L . Insulin resistance and insulin deficiency in the pathogenesis of posttransplantation diabetes in man. Transplantation. 1992; 53(3):563-9. DOI: 10.1097/00007890-199203000-00014. View

Kawahara D, KENNEY J . Species differences in human and rat islet sensitivity to human cytokines. Monoclonal anti-interleukin-1 (IL-1) influences on direct and indirect IL-1-mediated islet effects. Cytokine. 1991; 3(2):117-24. DOI: 10.1016/1043-4666(91)90031-8. View

Sollinger H, Geffner S . Pancreas transplantation. Surg Clin North Am. 1994; 74(5):1183-95. View

Martin F, Bedoya F . Short-term effects of cyclosporine on secretagogue-induced insulin release by isolated islets. Transplantation. 1990; 50(4):551-3. DOI: 10.1097/00007890-199010000-00003. View

Nathan D, Genuth S, Lachin J, Cleary P, Crofford O, Davis M . The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993; 329(14):977-86. DOI: 10.1056/NEJM199309303291401. View

Mandrup-Poulsen T, Bendtzen K, Dinarello C, Nerup J . Human tumor necrosis factor potentiates human interleukin 1-mediated rat pancreatic beta-cell cytotoxicity. J Immunol. 1987; 139(12):4077-82. View

Warnock G, Kneteman N, Ryan E, Rabinovitch A, Rajotte R . Long-term follow-up after transplantation of insulin-producing pancreatic islets into patients with type 1 (insulin-dependent) diabetes mellitus. Diabetologia. 1992; 35(1):89-95. DOI: 10.1007/BF00400857. View

Davalli A, Scaglia L, Zangen D, Hollister J, Bonner-Weir S, Weir G . Vulnerability of islets in the immediate posttransplantation period. Dynamic changes in structure and function. Diabetes. 1996; 45(9):1161-7. DOI: 10.2337/diab.45.9.1161. View

Eisenbarth G . Type I diabetes mellitus. A chronic autoimmune disease. N Engl J Med. 1986; 314(21):1360-8. DOI: 10.1056/NEJM198605223142106. View

10.

Lampeter E, Homberg M, Quabeck K, Schaefer U, Wernet P, Bertrams J . Transfer of insulin-dependent diabetes between HLA-identical siblings by bone marrow transplantation. Lancet. 1993; 341(8855):1243-4. DOI: 10.1016/0140-6736(93)91148-f. View

11.

Wang Q, Klein R, Moss S, Klein B, Hoyer C, Burke K . The influence of combined kidney-pancreas transplantation on the progression of diabetic retinopathy. A case series. Ophthalmology. 1994; 101(6):1071-6. DOI: 10.1016/s0161-6420(94)31216-4. View

12.

Zehr P, Milde F, Hart L, Corry R . Life quality of pancreatic transplant recipients: a comparison. Transplant Proc. 1992; 24(3):850-1. View

13.

Merrell R, Mahoney M, Basadonna G, Cobb L, Maeda M . Failure of canine islet allografts and autografts with cyclosporine. Surgery. 1985; 98(2):324-9. View

14.

Soldevila G, Buscema M, Doshi M, James R, Bottazzo G, Pujol-Borrell R . Cytotoxic effect of IFN-gamma plus TNF-alpha on human islet cells. J Autoimmun. 1991; 4(2):291-306. DOI: 10.1016/0896-8411(91)90025-8. View

15.

BOOKMAN J, DRACHMAN S, SCHAEFER L, ADLERSBERG D . Steroid diabetes in man; the development of diabetes during treatment with cortisone and corticotropin. Diabetes. 1953; 2(2):100-11. DOI: 10.2337/diab.2.2.100. View

16.

Gotoh M, Maki T, Satomi S, Porter J, Monaco A . Immunological characteristics of purified pancreatic islet grafts. Transplantation. 1986; 42(4):387-90. DOI: 10.1097/00007890-198610000-00011. View

17.

Yasunami Y, Ryu S, Kamei T . FK506 as the sole immunosuppressive agent for prolongation of islet allograft survival in the rat. Transplantation. 1990; 49(4):682-6. DOI: 10.1097/00007890-199004000-00005. View

18.

Harris M, Hadden W, Knowler W, BENNETT P . Prevalence of diabetes and impaired glucose tolerance and plasma glucose levels in U.S. population aged 20-74 yr. Diabetes. 1987; 36(4):523-34. DOI: 10.2337/diab.36.4.523. View

19.

Hayek A, Lopez A, Beattie G . Angiogenic peptides in pancreatic islet transplantation to diabetic rats. Transplantation. 1990; 50(6):931-3. DOI: 10.1097/00007890-199012000-00005. View

20.

Sato N, Irie M, KAJINUMA H, Suzuki K . Glucagon inhibits insulin activation of glucose transport in rat adipocytes mainly through a postbinding process. Endocrinology. 1990; 127(3):1072-7. DOI: 10.1210/endo-127-3-1072. View