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Biosynthetic Pathway of Citrinin in the Filamentous Fungus Monascus Ruber As Revealed by 13C Nuclear Magnetic Resonance

Overview
Journal Appl Environ Microbiol
Specialties Environmental Health
Microbiology
Date 1999 Jan 5
PMID 9872798
Citations 38
Authors
Hajjaj
Klaebe
LORET
Goma
BLANC
FRANCOIS
Affiliations
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Abstract

Carbon isotope distribution of [13C]citrinin from Monascus ruber incubated with [13C]acetate revealed that the biosynthesis of the toxin originated from a tetraketide, instead of a pentaketide as has been shown for Penicillium and Aspergillus species. The production of polyketide red pigments and citrinin by M. ruber may therefore be regulated at the level of the tetraketide branch point.

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References
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