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A Humanized Monoclonal Antibody Produced in Transgenic Plants for Immunoprotection of the Vagina Against Genital Herpes

Overview
Journal Nat Biotechnol
Specialty Biotechnology
Date 1998 Dec 16
PMID 9853620
Citations 49
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Abstract

The ability to produce monoclonal antibodies (Mabs) in plants offers the opportunity for the development of an inexpensive method of mucosal immunoprotection against sexually transmitted diseases. To investigate the suitability of plant-expressed Mabs for vaginal preventive applications, we compared a humanized anti-herpes simplex virus 2 (HSV-2) Mab expressed in mammalian cell culture with the same antibody expressed in soybean. We found these Mabs to be similar in their stability in human semen and cervical mucus over 24 h, their ability to diffuse in human cervical mucus, and their efficacy for prevention of vaginal HSV-2 infection in the mouse.

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