Modulating the Th1/Th2 Balance in Inflammatory Arthritis

Overview

Journal Springer Semin Immunopathol

Specialty Allergy & Immunology

Date 1998 Dec 4

PMID 9836376

Citations 12

Authors

B Muller

U Gimsa

N A Mitchison

A Radbruch

J Sieper

Z Yin

Affiliations

Soon will be listed here.

Abstract

The balance between Th1 and Th2 cells regulates the choice between inflammatory and antibody-mediated immune responses. To an increasing extent this balance is thought to involve the participation of antigen-presenting cells, rather than the entirely autonomous activity of T cells and their cytokines. Here we survey current opinion concerning the working of this balance, and its condition in rheumatoid arthritis and the other inflammatory arthritides. The contrast between Lyme arthritis and reactive arthritis is particularly illuminating, since one is triggered by extracellular and the other by intracellular infection. We describe current approaches to the modulation of this balance. Guided by the principles that genetic polymorphism is likely to identify relevant genes, that any cytokine gene picked up by a virus must matter and that natural immunosuppressive activity at mucosal surfaces should be worth exploiting, we identify as particularly worthy of attention: (i) IL-10, (ii) inhibitors of IL-12 production, (iii) inhibitors of CD40 ligand expression and (iv) oral and nasal tolerance. Other protective T cell subsets are touched on, and the impact of oligonucleotide arrays mentioned.

Citing Articles

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References

Piccinni M, Giudizi M, Biagiotti R, Beloni L, Giannarini L, Sampognaro S . Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell clones. J Immunol. 1995; 155(1):128-33. View

Dolhain R, van der Heiden A, ter Haar N, Breedveld F, Miltenburg A . Shift toward T lymphocytes with a T helper 1 cytokine-secretion profile in the joints of patients with rheumatoid arthritis. Arthritis Rheum. 1996; 39(12):1961-9. DOI: 10.1002/art.1780391204. View

Rogge L, Biffi M, Passini N, Presky D, Gubler U, Sinigaglia F . Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J Exp Med. 1997; 185(5):825-31. PMC: 2196163. DOI: 10.1084/jem.185.5.825. View

Mitchison A . Partitioning of genetic variation between regulatory and coding gene segments: the predominance of software variation in genes encoding introvert proteins. Immunogenetics. 1997; 46(1):46-52. DOI: 10.1007/s002510050241. View

Chomarat P, Vannier E, Dechanet J, Rissoan M, Banchereau J, Dinarello C . Balance of IL-1 receptor antagonist/IL-1 beta in rheumatoid synovium and its regulation by IL-4 and IL-10. J Immunol. 1995; 154(3):1432-9. View

Yin Z, Braun J, Neure L, Wu P, Eggens U, Krause A . T cell cytokine pattern in the joints of patients with Lyme arthritis and its regulation by cytokines and anticytokines. Arthritis Rheum. 1997; 40(1):69-79. DOI: 10.1002/art.1780400111. View

Berman R, Suzuki T, Tahara H, Robbins P, Narula S, Lotze M . Systemic administration of cellular IL-10 induces an effective, specific, and long-lived immune response against established tumors in mice. J Immunol. 1996; 157(1):231-8. View

Oliveira D, Mitchison N . Immune suppression genes. Clin Exp Immunol. 1989; 75(2):167-77. PMC: 1542112. View

Wilder R . Neuroendocrine-immune system interactions and autoimmunity. Annu Rev Immunol. 1995; 13:307-38. DOI: 10.1146/annurev.iy.13.040195.001515. View

10.

Eskdale J, Wordsworth P, Bowman S, Field M, Gallagher G . Association between polymorphisms at the human IL-10 locus and systemic lupus erythematosus. Tissue Antigens. 1997; 49(6):635-9. DOI: 10.1111/j.1399-0039.1997.tb02812.x. View

11.

Kanik K, Hagiwara E, Yarboro C, Schumacher H, Wilder R, Klinman D . Distinct patterns of cytokine secretion characterize new onset synovitis versus chronic rheumatoid arthritis. J Rheumatol. 1998; 25(1):16-22. View

12.

Kamradt T, Burmester G . Cytokines and arthritis: is the Th1/Th2 paradigm useful for understanding pathogenesis?. J Rheumatol. 1998; 25(1):6-8. View

13.

Austrup F, Vestweber D, Borges E, Lohning M, Brauer R, Herz U . P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflammed tissues. Nature. 1997; 385(6611):81-3. DOI: 10.1038/385081a0. View

14.

Yin Z, Braun J, Neure L, Wu P, Liu L, Eggens U . Crucial role of interleukin-10/interleukin-12 balance in the regulation of the type 2 T helper cytokine response in reactive arthritis. Arthritis Rheum. 1997; 40(10):1788-97. DOI: 10.1002/art.1780401010. View

15.

Brunner M, Larsen S, Sette A, Mitchison A . Altered Th1/Th2 balance associated with the immunosuppressive/protective effect of the H-2Ab allele on the response to allo-4-hydroxyphenylpyruvate dioxygenase. Eur J Immunol. 1995; 25(12):3285-9. DOI: 10.1002/eji.1830251213. View

16.

Simon A, Seipelt E, Wu P, Wenzel B, Braun J, Sieper J . Analysis of cytokine profiles in synovial T cell clones from chlamydial reactive arthritis patients: predominance of the Th1 subset. Clin Exp Immunol. 1993; 94(1):122-6. PMC: 1534378. DOI: 10.1111/j.1365-2249.1993.tb05988.x. View

17.

Pladevall-Vila M, Delclos G, Varas C, Guyer H . Controversy of oral contraceptives and risk of rheumatoid arthritis: meta-analysis of conflicting studies and review of conflicting meta-analyses with special emphasis on analysis of heterogeneity. Am J Epidemiol. 1996; 144(1):1-14. DOI: 10.1093/oxfordjournals.aje.a008846. View

18.

Romagnani S, Parronchi P, DElios M, Romagnani P, Annunziato F, Piccinni M . An update on human Th1 and Th2 cells. Int Arch Allergy Immunol. 1997; 113(1-3):153-6. DOI: 10.1159/000237532. View

19.

Panina-Bordignon P, Mazzeo D, Lucia P, DAmbrosio D, Lang R, Fabbri L . Beta2-agonists prevent Th1 development by selective inhibition of interleukin 12. J Clin Invest. 1997; 100(6):1513-9. PMC: 508332. DOI: 10.1172/JCI119674. View

20.

Jacobson N, Szabo S, Zhong Z, Schreiber R, Darnell Jr J, Murphy K . Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J Exp Med. 1995; 181(5):1755-62. PMC: 2191986. DOI: 10.1084/jem.181.5.1755. View